Tailoring of anticancer drugs loaded in MWCNT/Poly(MMA-co-HEMA) nanosphere composite by using in situ microemulsion polymerization
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Synthesis of multi-walled carbon nanotube (MWCNT)/Poly(methyl methacrylate-co-2-hydroxyethyl methacrylate) P(MMA-co-HEMA) nanocomposite loaded with either of curcumin and its water soluble derivative as two models of anticancer drugs was achieved via in situ microemulsion polymerization technique by using different ratios from multi-walled carbon nanotube MWCNT to drug. The homogenous dispersion of MWCNTs inside the polymer matrix and well defined nano-spheres were proved by TEM and X-ray diffraction XRD. The performance of MWCNT/polymer nanocomposite as drug carrier was examined with respect to the drug content, entrapment efficiency, nano-sphere morphology, thermal stability and in-vitro drug release. Drugs could be loaded in higher content with high Entrapment Efficiency values with improved thermal stability that increased with MWCNT ratio. The in-vitro drug release studies from MWCNT/Poly(MMA-co-HEMA) nanocomposite showed prolonged controlled release in the intestinal fluid pH 7.4 and lost a few amount ≤ 8% of the drug in the stomach fluid pH 1.2.
KeywordsMWCNTs/polymer nanocomposite Micro-emulsion polymerization Anticancer drugs
We acknowledge the funding agencies National Research centre, Egypt (Project Number 10140004).
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflictof interest.
Research involving human and animal participants
This article does not contain any studies with human or animal subjects performed by any of the authors.
- Albalawi AM, Mohamed WS, Elsayed NH (2016) Utilization of MMT clay and MMT-Chitosan for platinol drug delivery. Der Pharm Chem 8(23):27–34Google Scholar
- Al-Osaimi J, Alhosiny N, Badawi A, Abdallah S (2013) The effects of CNTs types on the structural and electrical properties of CNTs/PMMA nanocomposite films. Int J Eng Technol 13:77–79Google Scholar
- Athira GK, Jyothi AN (2014) Preparation and characterization of curcumin loaded cassava starch nanoparticles with improved cellular absorption. Int J Pharm Pharm Sci 6:171–176Google Scholar
- Baviskar DT, Tamkhane CM, Maniyar AH, Jain DK (2012) Carbon nanotubes: an emerging drug delivery tool in nanotechnology. Int J Pharm Pharm Sci 4:11–15Google Scholar
- Daum N, Tscheka C, Schneider ANM (2012) Novel approaches for drug delivery system in nanomedicine: effects of particle design and shape. Wiley Interdiscip Rev 4:52–65Google Scholar
- Gopi G, Kannan K (2015) Fabrication and in vitro evaluation of nateglinide-loaded ethyl cellulose nanoparticles. Asian J Pharm Clin Res 8:93–96Google Scholar
- Kumar SSD, Mahadevan S, Vijayaraghavan R, Mandal AB, MacFarlane DR (2014) Curcumin loaded poly(2-hydroxyethlene methacrylate) nanoparticles from gelled ionic liquid—in vitro cytotoxicity and anti-cancer activity in SKOV-3 cells. J Pharm Sci 51:34–44Google Scholar
- Kumar A, Singh M, Singh PP, Singh SK, Raj P, Pandey KD (2016) Antioxidant efficacy and curcumin content of turmeric (Curcuma-Longa L.) flower. Int J Curr Pharm Res 8:112–114Google Scholar
- Mali N, Jadhav S, Karpe M, Kadam V (2011) Carbon nanotubes as carriers for delivery of bioactive and therapeutic agents: an overview. Int J Pharm Pharm Sci 3:45–52Google Scholar
- Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y (2012) Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s disease. PLoS ONE 7:32–61Google Scholar
- Mukerjee A, Vishwanatha JK (2009) Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 29:3867–3875Google Scholar
- Rezq AM, Abdel Aziz MT, Al-Malki AL (2011) Gelatin, a novel curcumin drug carrier system. WO/2011/100984. https://www.google.com/patents/WO2011100984A1?cl=en
- Sharma S, Saraogi GK, Kumar V (2015) Development of spectrophotometric methods for simultaneous determination of artesunate and curcumin in a liposomal formulation. Int J App Pharm 7:18–21Google Scholar
- Thorat YS, Sarvagod AM, Kulkarni SV, Hosmani AH (2015) Treatment of mouth ulcer by curcumin loaded thermoreversible mucoadhesive gel: a technical note. Int J Pharm Pharm Sci 7:399–402Google Scholar