Efficacy of electrochemically activated water solution in gingivitis treatment

  • Truong Nhu Ngoc Vo
  • Dinh-Toi Chu
  • Duc Long Duong
  • Van Nhon Bui
  • Minh Son Tong
  • Thi Thu Phuong Nguyen
  • Quynh Anh Le
  • Khanh-Hoang Nguyen
  • Van-Huy Pham
  • Thien Chu-Dinh
Original Article


Mouthwash is one of the most commonly oral healthcare products for prevention and treatment of gum diseases. Dr. ECA is a disinfectant solution manufactured by a Vietnamese company and has been licensed for oral healthcare, but its effect on gingivitis is still unclear. To evaluate the effectiveness of this product in the treatment of gingivitis, we conducted a clinical study in 60 students diagnosed with gingivitis to compare the results of gingivitis treatment using Dr. ECA and a control mouthwash (a demonstrated anti-gingivitis product). The data showed that in the treated group, the rate of good Gingivitis Index (GI) before treatment was 46.67%, but after 2 and 4 weeks of using Dr. ECA that rate was increased to 96.67% and 100%, respectively. The percentage of patients with bleeding on probing was 63.33% but declined sharply after 2 weeks of treatment to 6.67%, and further reduced to 3.33% after 4 weeks of treatment. The treatment outcomes in were similar in the Dr. ECA treated group and control one with no statistically significant difference. Our results suggest that the electrolyte saline solution Dr. ECA is effective in treating gingivitis. Its effects are similar to other mouthwash products that had been approved and marketed.


Mouthwash Electrochemically activated water solutions Dr. ECA Gingivitis 


Author Contributions

TNNV and DTC designed experiments. VTNV, DLD, VNB and MST, TTPN and QAL designed, performed experiments, and collected data and informed consents. TNNV, DTC, KHN, VHP, and TCD analyzed and interpreted the results. VTNV, DLD, DTC, VHP, and TCD wrote the manuscript. DTC, KHN, VHP, and TCD edited the manuscript. All authors approved the final manuscript.


The EVD Group provided Dr. ECA solution and a part of the expenses for this research.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the Hanoi Medical University’s Ethics Council committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Hanoi Medical University’s Ethics Council committee (No. 121/HMU IRB).

Informed consent

Informed consent was obtained from the patients included in the study.


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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2018

Authors and Affiliations

  1. 1.School of Odonto StomatologyHanoi Medical UniversityHanoiVietnam
  2. 2.Faculty of BiologyHanoi National University of EducationHanoiVietnam
  3. 3.Centre for Molecular Medicine Norway (NCMM), Nordic EMBL PartnershipUniversity of Oslo and Oslo University HospitalOsloNorway
  4. 4.Department of Science and Technology ManagementHanoi Medical UniversityHanoiVietnam
  5. 5.National Food InstituteTechnical University of DenmarkKongens LyngbyDenmark
  6. 6.AI Lab, Faculty of Information TechnologyTon Duc Thang UniversityHo Chi Minh CityVietnam
  7. 7.Institute for Research and DevelopmentDuy Tan UniversityDanangVietnam

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