Albumin-based potential drugs: focus on half-life extension and nanoparticle preparation
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Albumin has been viewed as one of the most useful and versatile carrier proteins in pharmaceutical and clinical fields. Albumin is biocompatible and non-toxic, and so can be used as a pharmaceutical carrier more safely versus many synthetic polymers. Importantly, albumin has great ability to extend circulating half-lives of short-lived peptides and protein drugs when they are properly linked because albumin is hardly filtered in the glomerulus due to its large size (~66.4 kDa). Albumin is also an excellent material to construct nanoparticles because it has good physicochemical stability, targetability, and chemical functionality. In the first part of this review, three major methods for half-life extension of peptide/protein drugs using endogenous or exogenous albumin are described: physical non-covalent binding, covalent binding, and albumin-fusion. The second part details the most intensively utilized methods for nanoparticle preparation: desolvation, nanoparticle albumin bound (Nab™) technology, and self-assembly. The review provides in-depth understanding for albumin-based drugs and their nano-delivery.
KeywordsAlbumin Half-life extension Nanoparticles Targeting Cancer Diabetes
All authors (E. S. Lee and Y. S. Youn) declare that they have no conflict of interest. This article does not contain any studies with human or animal subjects performed by any of the authors. The corresponding author Y. S. Youn would like to express special thanks to the past Dr. Tae Hyung Kim for this review work. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning (NRF-2014R1A2A2A05002133).
- Desai N, Trieu V, Yao Z, Louie L, Ci S, Yang A, Tao C, De T, Beals B, Dykes D, Noker P, Yao R, Labao E, Hawkins M, Soon-Shiong P (2006) Increased antitumor activity, intratumor paclitaxel concentrations, and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI–007, compared with cremophor–based paclitaxel. Clin Cancer Res 12(4):1317–1324CrossRefPubMedGoogle Scholar
- Kim TH, Jiang HH, Youn YS, Park CW, Lim SM, Jin CH, Tak KK, Lee HS, Lee KC (2011b) Preparation and characterization of Apo2L/TNF-related apoptosis-inducing ligand-loaded human serum albumin nanoparticles with improved stability and tumor distribution. J Pharm Sci 100(2):482–491CrossRefPubMedGoogle Scholar
- Wagner S, Rothweiler F, Anhorn MG, Sauer D, Riemann I, Weiss EC, Katsen-Globa A, Michaelis M, Cinatl J Jr, Schwartz D, Kreuter J, von Briesen H, Langer K (2010) Enhanced drug targeting by attachment of an anti alphav integrin antibody to doxorubicin loaded human serum albumin nanoparticles. Biomaterials 31(8):2388–2398CrossRefPubMedGoogle Scholar