Journal of Pharmaceutical Investigation

, Volume 43, Issue 2, pp 133–143 | Cite as

Mathematical optimization and characterisation of pharmaceutically developed novel buccoadhesive wafers for rapid bioactive delivery of Loratadine

  • Prithviraj Chakraborty
  • Versha Parcha
  • Debarupa D. Chakraborty
  • Indranil Chanda
  • Amitava Ghosh
Research Article

Abstract

The purpose of this study was to develop pharmaceutically active buccoadhesive wafer formulations containing Loratadine and mathematically optimize the influence of bioadhesive polymer Sod. CMC and Lactose monohydrate as an ingredient of wafer base matrix, on the physicochemical and drug release performance from the prepared wafers. The wafers, which were prepared by the solvent casting method, were smooth and elegant in appearance; uniform in thickness, weight and drug content; showed no visible cracks; and demonstrated good folding endurance. A 32 factorial design was employed to study the effect of independent variables like Sod.CMC and Lactose monohydrate, which significantly influenced characteristics like buccoadhesion, swelling index, disintegration time and t70 % of the prepared wafers. The drug-excipients interaction studies performed by ATR-FTIR, DSC and XRD revealed drug polymer compatibility within the wafer formulation. Surface morphology of the prepared wafers were studied by using SEM. Drug release study in the buccal environment showed the efficacy of the wafers to release drug within a very short span of time. Thus a conclusion might be brought forward that the present buccal wafer formulation could be an ideal system improving the bioavailability of the drug by avoiding hepatic first pass metabolism and would be an ideal alternative for the patients suffering with dysphagia.

Keywords

Wafer Mathemetical optimization  Buccoadhesive RSM Loratadine 

Notes

Acknowledgments

The authors are thankful to Department of Pharmaceutical Sciences; Dibrugarh University, Assam, India, for providing DSC facility, Department of Metallurgy, Jadavpur University, Kolkata, India for providing SEM and XRD facilities and Prof. (Dr.) S.K Dash and Mr. Pulak Deb, Girijananda Institute of Pharmaceutical Sciences, Guwahati, Assam, India, for providing TAXT2i Texture Analyzer facility.

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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2013

Authors and Affiliations

  • Prithviraj Chakraborty
    • 1
  • Versha Parcha
    • 2
  • Debarupa D. Chakraborty
    • 1
  • Indranil Chanda
    • 3
  • Amitava Ghosh
    • 1
  1. 1.Bengal College of Pharmaceutical Sciences and ResearchDurgapurIndia
  2. 2.Department of ChemistrySardar Bhagwan Singh PG Institute of Biomedical Sciences and ResearchDehradunIndia
  3. 3.Girijananda Chowdhury Institute of Pharmaceutical ScienceGuwahatiIndia

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