Eckpfeiler der Prävention
Hypertonie und die Folgen für kognitive Funktionsstörungen und Demenz
Zertifizierte Fortbildung
First Online:
- 58 Downloads
Zusammenfassung
Immer mehr Menschen erkranken an einer Demenz. Die Demenz entwickelt sich daher zu einer immensen Herausforderung in älter werdenden Gesellschaften. Entscheidend für die Prävention ist es, wesentliche Risikofaktoren einer Demenz rechtzeitig zu erkennen und zu behandeln – zweifellos gehört hierzu auch die Behandlung der arteriellen Hypertonie.
Literatur
- 1.Peltz CB, Corrada MM, Berlau DJ, Kawas CH. Cognitive impairment in nondemented oldest-old: Prevalence and relationship to cardiovascular risk factors. Alzheimers Dement. 2012;8(2):87–94CrossRefPubMedPubMedCentralGoogle Scholar
- 2.Knecht S, Berger K. Einfluss vaskulärer Faktoren auf die Entwicklung einer Demenz. Dtsch Arztebl International. 2004;101(31-32): p. A–2185Google Scholar
- 3.Lüders S, Stöve S, Schrader J. Prävention der vaskulären Demenz. Internist 2012;53:223–31CrossRefPubMedGoogle Scholar
- 4.Lüders S, Schrader J. Vaskuläre Demenz und Hypertonie. Dtsch med Wochenschr. 2015;140(21):1599–603.CrossRefPubMedGoogle Scholar
- 5.Rönnemaa E, Zethelius B, Lannfelt L, Kilander L. Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort. Dement Geriatr Cogn Disord. 2011;31(6):460–6CrossRefPubMedGoogle Scholar
- 6.Lüders S, Saathoff U, Haller H et al. Häufigkeit kognitiver Funktionsstörungen bei Patienten mit Begleiterkrankungen. Ergebnisse des DEMTECT-Registers der Schlaganfall-Kommission der Deutschen Hypertonie-Gesellschaft. DHL-Kongress, Berlin 2012Google Scholar
- 7.Brayne C, Ince PG, Keage HAD et al. Education, the brain and dementia: neuroprotection or compensation? Brain. 2010;133(8):2210–6CrossRefPubMedGoogle Scholar
- 8.Leys D, Henon H, Mackowiak-Cordoliani MA et al. Poststroke dementia. Lancet Neurol. 2005;4:752–9CrossRefPubMedGoogle Scholar
- 9.Novak V, Hajjar I. The relationship between blood pressure and cognitive function. Nat Rev Cardiol. 2010;7:686–98PubMedPubMedCentralGoogle Scholar
- 10.O’Donnell MJ, Xavier D, Liu L et al. Risk factors for ischemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010;376:112–23CrossRefPubMedGoogle Scholar
- 11.Tu JV. Reducing the global burden of stroke. Lancet. 2010;376:74–5CrossRefPubMedGoogle Scholar
- 12.Vermeer SE, Prins ND, den Heijer T et al. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2013;348:1215–22CrossRefGoogle Scholar
- 13.Bernick C, Kuller L, Dulberg C et al. Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology. 2001;57:1222–29CrossRefPubMedGoogle Scholar
- 14.Watanabe N, Imai Y, Nagai K et al. Nocturnal blood pressure and silent cerebovascular lesions in elderly Japanese. Stroke. 1996;27:1319–27CrossRefPubMedGoogle Scholar
- 15.Launer LJ, Ross GW, Petrovitch H et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49–55CrossRefPubMedGoogle Scholar
- 16.Freitag MH, Peila R, Masaki K et al. Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study. Stroke. 2006;37(1):33–7CrossRefPubMedGoogle Scholar
- 17.Kivipelto M, Helkala EL, Laakso MP et al. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med. 2002;137(3):149–55CrossRefPubMedGoogle Scholar
- 18.Launer LJ, Masaki K, Petrovitch H et al. The association between midlife blood pressure levels and late-life cognitive function. JAMA. 1995;274:1846–51CrossRefPubMedGoogle Scholar
- 19.Morris MC, Scherr PA, Hebert LE et al. Association of incident Alzheimer’s disease and blood pressure measured from 13 years before to 2 years after diagnosis in a large community study. Arch Neurol. 2001;58:1640–46CrossRefPubMedGoogle Scholar
- 20.Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005;4(8):487–99CrossRefPubMedGoogle Scholar
- 21.Knecht S, Wersching H, Lohmann H et al. High-normal blood pressure is associated with poor cognitive performance. Hypertension. 2008;51(3): 663–8CrossRefPubMedGoogle Scholar
- 22.Kalaria RN. Vascular basis for brain degeneration: faltering controls and risk factors for dementia. Nutr Rev. 2010;68 Suppl 2:S74–87CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Beauchet O, Celle S, Roche F et al. Blood pressure levels and brain volume reduction: a systematic review and meta-analysis. J Hypertens. 2013; 1(8):1502–16CrossRefGoogle Scholar
- 24.Skoog I, Lernfelt B, Landahl S et al. A. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–5CrossRefPubMedGoogle Scholar
- 25.Stewart R, Xue QL, Masaki K et al. Change in blood pressure and incident dementia: a 32-year prospective study. Hypertension. 2009;54(2):233–40CrossRefPubMedPubMedCentralGoogle Scholar
- 26.Kilander L, Nyman H, Boberg M et al. Hypertension Is Related to Cognitive Impairment: A 20-Year Follow-up of 999 Men. Hypertension. 1998;31(3):780–6CrossRefPubMedGoogle Scholar
- 27.Sharp SI, Aarsland D, Day S et al. Hypertension is a potential risk factor for vascular dementia: systematic review. Int J Geriatr Psychiatry. 2011;26(7):661–9CrossRefPubMedGoogle Scholar
- 28.Ueda K, Kawano H, Hasuo Y, Fujishima M. Prevalence and etiology of dementia in a Japanese community. Stroke. 1992;23(6):798–803CrossRefPubMedGoogle Scholar
- 29.Yoshitake T, Kiyohara Y, Kato I et al. Incidence and risk factors of vascular dementia and Alzheimer’s disease in a defined elderly Japanese population: the Hisayama Study. Neurology. 1995;45(6):1161–8CrossRefPubMedGoogle Scholar
- 30.Power MC, Weuve J, Gagne JJ et al. The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis. Epidemiology. 2011;22(5):646–59CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Meng XF, Yu JT, Wang HF et al. Midlife vascular risk factors and the risk of Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;42(4):1295–310PubMedGoogle Scholar
- 32.Corrada M. Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study. Alzheimer’s Association International Conference 2014, Abstract P2–083Google Scholar
- 33.Gorelick PB, Scuteri A, Black SE et al. Vascular Contributions to Cognitive Impairment and Dementia. A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2011;42:2672–713CrossRefPubMedPubMedCentralGoogle Scholar
- 34.Haag MDM, Hofman A, Koudstaal PJ et al. Duration of antihypertensive drug use and risk of dementia. A prospective cohort study. Neurology. 2009;72:1727–34CrossRefPubMedGoogle Scholar
- 35.Forette F, Seux ML, Staessen JA et al. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med. 2002;162(18):2046–52CrossRefPubMedGoogle Scholar
- 36.Peila R, White LR, Masaki K et al. Reducing the risk of dementia. Efficacy of long-term treatment of hypertension. Stroke. 2006;37:1165–70CrossRefPubMedGoogle Scholar
- 37.Tzourio C, Anderson C, Chapman N et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med. 2003;163:1069–75CrossRefPubMedGoogle Scholar
- 38.Peters R, Beckett N, Forette F et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet. 2008;7:683–9CrossRefPubMedGoogle Scholar
- 39.Sugiyama T, Lee JD, Shimizu H et al. Influence of treated blood pressure on progression of silent cerebral infarction. J Hypertens. 1999;17:679–84CrossRefPubMedGoogle Scholar
- 40.Duron E, Rigaud AS, Dubail D et al. Effects of antihypertensive therapy on cognitive decline in Alzheimer’s disease. Am J Hypertens. 2009;22:1020–4CrossRefPubMedGoogle Scholar
- 41.Böhm M, Schumacher H, Leong D et al. Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk. Hypertension. 2015;65(3):651–61CrossRefPubMedGoogle Scholar
- 42.van der Wardt V, Logan P, Conroy S et al. Antihypertensive Treatment in People With Dementia. J Am Med Dir Assoc. 2014;15(9):620–9CrossRefPubMedGoogle Scholar
- 43.Beishon LC, Harrison JK, Harwood RH et al. The evidence for treating hypertension in older people with dementia: a systematic review. J Hum Hypertens. 2014;28(5):283–7CrossRefPubMedGoogle Scholar
- 44.Ohrui T, Tomita N, Sato-Nakagawa T et al. Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression. Neurology. 2004;63(7):1324–5CrossRefPubMedGoogle Scholar
- 45.Kaiser EA, Lotze U, Schäfer HH. Increasing complexity: which drug class to choose for treatment of hypertension in the elderly? Clin Interv Aging. 2014;9:459–75PubMedPubMedCentralGoogle Scholar
- 46.Lehrl S, Gräßel E, Eicke C. Wirkung von Felodipin bei hypertonen Patienten mit leichten Hirnleistungsstörungen in einer randomisierten Doppelblindstudie. Dtsch med Wochenschr. 2000;125(45):1350–6CrossRefPubMedGoogle Scholar
- 47.Tedesco MA, Ratti G, Mennella S et al. Comparison of losartan and hydrochlorothiazide on cognitive function and quality of life in hypertensive patients. Am J Hypertension. 1999;12:1130–4CrossRefGoogle Scholar
- 48.Inaba S, Iwai M, Furuno M et al. Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice. Hypertension. 2009;53:356CrossRefPubMedGoogle Scholar
- 49.Wright JW, Harding JW. The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer’s disease. J Renin Angiotensin Aldosterone Syst. 2008;9(4):226–37CrossRefPubMedGoogle Scholar
- 50.Xie W, Zhu D, Ji L et al. Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion. Brain Res. 2014;1573:44–53CrossRefPubMedGoogle Scholar
- 51.Sink KM, Leng X, Williamson J et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension. Arch Intern Med. 2009;169(13):1195–202CrossRefPubMedPubMedCentralGoogle Scholar
- 52.Chiu WC, Ho WC, Lin MH et al. Angiotension receptor blockers reduce the risk of dementia. J Hypertens. 2014;32(4):938–47CrossRefPubMedGoogle Scholar
- 53.Fogari R, Preti P, Mugellini A et al. Influence of losartan and atenolol on cognitive function in very elderly hypertensive patients. Am J Hypertens. 2002;15:36AGoogle Scholar
- 54.Levi Marpillat N, Macquin-Mavier I, Tropeano AI et al. Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. J Hypertens. 2013;31(6):1073–82CrossRefPubMedGoogle Scholar
- 55.Schrader J, Lüders S, Kulschewski A et al. MOSES Study Group. Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke. 2005;36(6):1218–26CrossRefPubMedGoogle Scholar
- 56.Gelber RP, Ross GW, Petrovitch H et al. Antihypertensive medication use and risk of cognitive impairment: The Honolulu-Asia Aging Study. Neurology. 2013;81(10):888–95CrossRefPubMedPubMedCentralGoogle Scholar
Copyright information
© Springer Medizin 2016