pädiatrie hautnah

, Volume 25, Issue 4, pp 246–251

Eine besondere therapeutische Herausforderung

Hyperhidrose
  • Sarah Basedow
  • Roland Kruse
  • Daniela Bruch-Gerharz
Fortbildung
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Bei der Hyperhidrose handelt es sich um eine örtlich umschriebene oder generalisiert auftretende übermäßige Schweißbildung mit Krankheitswert. Da das übermäßige Schwitzen oftmals schon im Kindesalter beginnt, stellt die Hyperhidrose eine bedeutsame Erkrankung des Kindes- und Jugendalters dar. Darüber hinaus liegt häufig eine therapeutische Herausforderung vor, da die meisten handelsüblichen Therapeutika nicht für das Kindes- und Jugendalter zugelassen sind.

Literatur

  1. 1.
    Baumgartner FJ, Bertin S, Konecny J (2009) Superiority of thoracoscopic sympathectomy over medical management for the palmoplantar subset of severe hyperhidrosis. Ann Vasc Surg 23:1–7PubMedCrossRefGoogle Scholar
  2. 2.
    Bechara FG, Sand M, Tomi NS et al (2007) Repeat liposuction-curettage treatment of axillary hyperhidrosis is safe and effective. Br J Dermatol 157:739–743PubMedCrossRefGoogle Scholar
  3. 3.
    Bellet JS (2010) Diagnosis and treatment of primary focal hyperhidrosis in children and adolescents. Semin Cutan Med Surg 29:121–126PubMedCrossRefGoogle Scholar
  4. 4.
    Benohanian A, Dansereau A, Bolduc C, Bloom E (1998) Localized hyperhidrosis treated with aluminium chloride in a salicylic acid gel base. Int J Dermatol 37:701–703PubMedCrossRefGoogle Scholar
  5. 5.
    Buraschi J (2008) Videothoracoscopic sympathicolysis procedure for primary palmar hyperhidrosis in children and adolescents. Arch Argent Pediatr 106:32–35PubMedGoogle Scholar
  6. 6.
    Chu EC, Chu NS (1997) Patterns of sympathetic skin response in palmar hyperhidrosis. Clin Auton Res 7:1–4PubMedCrossRefGoogle Scholar
  7. 7.
    Coutinho dos Santos LH, Gomes AM, Giraldi S et al (2009) Palmar hyperhidrosis: long-term follow-up of nine children and adolescents treated with botulinum toxin type A. Pediatr Dermatol 26:439–444PubMedCrossRefGoogle Scholar
  8. 8.
    Flanagan KH, Glaser DA (2009) An open-label trial of the efficacy of 15% aluminium chloride in 2% salicylic acid gel base in the treatment of moderate-to-severe primary axillary hyperhidrosis. J Drugs Dermatol 8:477–480PubMedGoogle Scholar
  9. 9.
    Gelbard CM, Epstein H, Hebert A (2008) Primary pediatric hyperhidrosis: a review of current treatment options. Pediatr Dermatol 25:591–598PubMedCrossRefGoogle Scholar
  10. 10.
    Haider A, Solish N (2005) Focal hyperhidrosis: diagnosis and management. CMAJ 172:69–75PubMedGoogle Scholar
  11. 11.
    Heckmann M (2005) Erkrankungen der Schweißdrüsen. In: Braun-Falco O, Plewig G, Wolff HH et al (Hrsg) Dermatologie und Venerologie. Springer, Berlin, S 910–922Google Scholar
  12. 12.
    Higashimoto I, Yoshiura K, Hirakawa N et al (2006) Primary palmar hyperhidrosis locus maps to 14q11.2-q13. Am J Med Genet A 140:567–572PubMedGoogle Scholar
  13. 13.
    Hölzle E (1983) Physiopathologic aspects and clinical pictures in hyperhidrosis. Hautarzt 34:596–604PubMedGoogle Scholar
  14. 14.
    Hölzle E (1984) Therapy of hyperhidrosis. Hautarzt 35:7–15Google Scholar
  15. 15.
    Hölzle E, Kligman AM (1979) Mechanism of antiperspirant action of aluminium salts. J Soc Cosmet Chem 30:279–295Google Scholar
  16. 16.
    Hölzle E, Reinauer S, Hund M, Lommel K (2004) Recommendations for standards of water iontophoresis. J Dtsch Dermatol Ges 2:956–962PubMedCrossRefGoogle Scholar
  17. 17.
    Hund M, Sinkgraven R, Rzany B (2004) Randomisierte, plazebokontrollierte Doppelblindstudie zur Wirksamkeitsbewertung und Sicherheit von Methantheliniumbromid (Vagantin) zur Behandlung der fokalen Hyperhidrose. J Dtsch Dermatol Ges 2:343–349PubMedCrossRefGoogle Scholar
  18. 18.
    Imhof M, Zacherl J, Plas EG et al (1999) Long term results of 45 thoracoscopic sympathicotomies for primary hyperhidrosis in children. J Pediatr Surg 34:1839-1842Google Scholar
  19. 19.
    Kreyden OP, Scheidegger EP (2004) Anatomy of the sweat glands, pharmacology of botulinum toxin and distinctive syndromes associates with hyperhidrosis. Clin Dermatol 22:40–44PubMedCrossRefGoogle Scholar
  20. 20.
    Lawrence CM, Lonsdale Eccles AA (2006) Selective sweat gland removal with minimal skin excision in the treatment of axillary hyperhidrosis: a retrospective clinical and histological review of 15 patients. Br J Dermatol 155:115–118PubMedCrossRefGoogle Scholar
  21. 21.
    Li X, Chen R, Tu YR et al (2007) Epidemiological survey of primary palmar hyperhidrosis in adolescents. Chin Med J (Engl) 120:2215–2217Google Scholar
  22. 22.
    Lowe N, Campanati A, Bodokh I et al (2004) The place of botulinum toxin type A in the treatment of focal hyperhidrosis. Br J Dermatol 151:1115–1122PubMedCrossRefGoogle Scholar
  23. 23.
    Reinauer S, Neusser A, Schauf G, Hölzle E (1993) Iontophoresis with alternating current offset (AC/DC iontophoresis): a new approach for the treatment of hyperhidrosis. Br J Dermatol 129:166–169PubMedCrossRefGoogle Scholar
  24. 24.
    Schlereth T, Dieterich M, Birklein F (2009) Hyperhidrosis — causes and treatment of enhanced sweating. Dtsch Arztebl Int 106:32–37PubMedGoogle Scholar
  25. 25.
    Sonntag M, Ruzicka T (2005) Hyperhidrose — Ursachen und aktuelle Behandlungsmöglichkeiten. Psychoneuro 31:315–320CrossRefGoogle Scholar
  26. 26.
    Sonntag M, Ruzicka T, Bruch-Gerharz D (2007) Treating excessive sweating with poison. Lancet 369:1327CrossRefGoogle Scholar
  27. 27.
    Steiner Z, Cohen Z, Kleiner O et al (2008) Do children tolerate thoracoscopic sympathectomy better than adults? Pediatr Surg Int 24:343–347PubMedCrossRefGoogle Scholar
  28. 28.
    Swartling C, Färnstrand C, Abt G et al (2001) Side-effects of intradermal injections of botulinum A toxin in the treatment of palmar hyperhidrosis: a neurophysiological study. Eur J Neurol 8:451–456PubMedCrossRefGoogle Scholar
  29. 29.
    Sugimura H, Spratt EH, Compeau CG et al (2009) Thoracoscopic sympathetic clipping for hyperhidrosis: long-term results and reversibility. J Thorac Cardiovasc Surg 137:1370–1377PubMedCrossRefGoogle Scholar
  30. 30.
    Weber A, Heger S, Sinkgraven R et al (2005) Psychosocial aspects of patients with focal hyperhidrosis. Marked reduction of social phobia, anxiety and depression and increased quality of life after treatment with botulinum toxin A. Br J Dermatol 152:342–345PubMedCrossRefGoogle Scholar
  31. 31.
    Wörle B, Rapprich S, Heckmann M (2007) Definition and treatment of primary hyperhidrosis. J Dtsch Dermatol Ges 5:625–628PubMedCrossRefGoogle Scholar

Copyright information

© Urban & Vogel 2013

Authors and Affiliations

  • Sarah Basedow
  • Roland Kruse
  • Daniela Bruch-Gerharz
    • 1
  1. 1.Hautklinik des Universitätsklinikums Düsseldorf, Heinrich-Heine-UniversitätDüsseldorfDeutschland

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