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Infection

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Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection

  • Sheng Bi
  • Xin Yao
  • Cheng Huang
  • Xia Zheng
  • Tianming Xuan
  • Jifang Sheng
  • Kaijin Xu
  • Beiwen ZhengEmail author
  • Qing YangEmail author
Case Report
  • 13 Downloads

Abstract

Introduction

A woman infected by carbapenem-resistant Klebsiella pneumoniae is reported in this study.

Case report

Tigecycline and meropenem combination was used, and indeed, in vitro checkerboard synergy test confirmed the antagonism between the two antibiotics. Thus, meropenem was ceased and single high-dose tigecycline was successful against the infection. Subsequent experiments showed that the isolates of the KPC-2-producing K. pneumoniae ST11 clone caused the infection.

Conclusion

Therefore, tigecycline and meropenem combination should be used with caution.

Keywords

Carbapenem-resistance KPC-2-producing Klebsiella pneumoniae Tigecycline Meropenem Antagonistic effect 

Notes

Funding

This study was supported by the following fundings: National Key Research and Development Program of China (No. 2016YFC1201603); National Natural Science Foundation of China (No. 81741098); Zhejiang Provincial Natural Science Foundation of China (No. LY17H190003).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This is a research involving a human participant.

Informed consent

The patient provided written informed consent to publish the clinical record.

Supplementary material

15010_2019_1274_MOESM1_ESM.pdf (40 kb)
Supplementary material 1 (PDF 40 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Sheng Bi
    • 1
  • Xin Yao
    • 2
  • Cheng Huang
    • 1
    • 3
  • Xia Zheng
    • 4
  • Tianming Xuan
    • 5
  • Jifang Sheng
    • 1
  • Kaijin Xu
    • 1
  • Beiwen Zheng
    • 1
    • 7
    Email author
  • Qing Yang
    • 6
    Email author
  1. 1.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  2. 2.Department of Gastroenterology, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  3. 3.Department of Respiratory Medicine, Lihuili HospitalNingbo Medical CenterNingboChina
  4. 4.Intensive Care Unit, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  5. 5.Department of Cardiovascular, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  6. 6.Center of Clinical Laboratory, The First Affiliated Hospital, School of MedicineZhejiang UniversityHangzhouChina
  7. 7.Institute of Animal QuarantineChinese Academy of Inspection and QuarantineBeijingChina

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