Vaccine strain Listeria monocytogenes bacteremia occurring 31 months after immunization
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Listeria monocytogenes is a food-borne, facultative intracellular bacterium that causes severe diseases such as sepsis and meningoencephalitis in immunocompromised hosts. Because it stimulates robust T-lymphocyte-mediated responses, attenuated L. monocytogenes are candidate vaccine vectors for tumor immunotherapy.
We report a case of bacteremia caused by vaccine strain L. monocytogenes (Axalimogene filolisbac) occurring 31 months after immunization against human papilloma virus (HPV) associated cervical cancer.
Receipt of a L. monocytogenes-based vaccine is a novel risk factor for delayed L. monocytogenes bacteremia.
KeywordsImmunotherapy Live vaccine Recurrent listeriosis. Listeria vaccine
The authors thank Jennifer C. Hunter and Brendan R. Jackson of the Centers for Disease Control and Prevention, Atlanta, GA for assistance with manuscript preparation. We also thank members of the CDC Enteric Diseases Laboratory Branch for pulsed-field electrophoresis analysis, whole-genome sequencing, and whole-genome sequencing analysis: Cheryl L. Tarr, Katie Roache, Zuzana Kucerova, Steven Stroika, and Lee S. Katz.
Compliance with ethical standards
Conflict of interest
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. EF, CM, LS, and DD are not affiliated with, nor received any funding from Advaxis, Inc. AG and MP are current employees of Advaxis, Inc.
The clinical trial under which the patient received experimental immunotherapy and subsequent review of her records were done with the approval of the Institutional Review Board at OUHSC.
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