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Infection

, Volume 47, Issue 1, pp 87–93 | Cite as

Interest of immunodeficiency screening in adult after admission in medical intensive care unit for severe infection, a retrospective and a prospective study: the Intensive Care Unit and Primary and Secondary Immunodeficiency (ICUSPID) study

  • Aurélie BaldolliEmail author
  • Nicolas Martin Silva
  • Amélie Seguin
  • Gwenola Maigne
  • Audrey Sultan
  • Samuel Deshayes
  • Damien Du Cheyron
  • Aurélie Joret
  • Nizar Mahlaoui
  • Boris Bienvenu
Brief Report
  • 91 Downloads

Abstract

Background

Primary immunodeficiency (PID) in adults is rare and mostly revealed by infections.

Material and Methods

Adults without predisposing factors who were admitted to an intensive care unit (ICU) for infection were screened for PID.

Results

Six PID cases were diagnosed, mostly revealed by encapsulated bacterial infections.

Conclusion

Investigation of PID after ICU discharge should be considered to improve early detection.

Keywords

Primary immunodeficiency Secondary immunodeficiency Infection Adult Intensive care unit 

Notes

Acknowledgements

The authors acknowledge the French National Reference Centre for PID, CEREDIH.

Author contributions

AB, NMS, GM, AS, AS, SD, DDC, AJ, NM and BB collected the data and drafted the report. AB, NMS, GM analyzed and interpreted the data. All authors read and approved the final report.

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Aurélie Baldolli
    • 1
    • 8
    Email author
  • Nicolas Martin Silva
    • 2
  • Amélie Seguin
    • 3
  • Gwenola Maigne
    • 2
  • Audrey Sultan
    • 2
  • Samuel Deshayes
    • 2
  • Damien Du Cheyron
    • 3
  • Aurélie Joret
    • 3
  • Nizar Mahlaoui
    • 4
    • 5
    • 6
  • Boris Bienvenu
    • 7
  1. 1.Department of Infectious DiseasesCHU de CaenCaenFrance
  2. 2.Department of Internal MedicineCHU de CaenCaenFrance
  3. 3.Department of Intensive Care UnitCHU de CaenCaenFrance
  4. 4.French National Reference Center for Primary Immune Deficiency (CEREDIH), Necker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de ParisParisFrance
  5. 5.Pediatric Immuno-Haematology and Rheumatology UnitNecker Enfants Malades University Hospital, Assistance Publique-Hôpitaux de ParisParisFrance
  6. 6.INSERM UMR1163, Imagine Institute, Sorbonne Paris Cité, University Paris DescartesParisFrance
  7. 7.Internal Medicine DepartmentSaint-Joseph HospitalMarseilleFrance
  8. 8.Groupe de Recherche sur l’Adaptation Microbienne (GRAM 2.0)Université Caen NormandieCaenFrance

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