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Infection

, Volume 46, Issue 5, pp 725–727 | Cite as

Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin

  • Elisa Biliotti
  • Cristiana Franchi
  • Martina Spaziante
  • Anna Rosa Garbuglia
  • Lorenzo Volpicelli
  • Donatella Palazzo
  • Maurizio De Angelis
  • Rozenn Esvan
  • Gloria Taliani
Case Report

Abstract

Introduction

Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking.

Case report

We report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. The treatment was capable of rapidly inducing both HCV and HEV viral suppression.

Conclusion

In conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.

Keywords

Hepatitis E Ribavirin Sofosbuvir Acute-on-chronic-liver-failure Hepatitis C 

Notes

Compliance with ethical standards

Conflict of interest

All authors have nothing to disclose regarding funding or conflict of interest with respect to this manuscript.

References

  1. 1.
    Peron JM, Abravanel F, Guillaume M, Gérolami R, Nana J, Anty R, et al. Treatment of autochthonous acute hepatitis E with short-term ribavirin: a multicenter retrospective study. Liver Int. 2016;36:328–33.CrossRefPubMedGoogle Scholar
  2. 2.
    Riveiro-Barciela M, Mınguez B, Girones R, Rodriguez-Frías F, Quer J, Buti M. Phylogenetic demonstration of hepatitis E infection transmitted by pork meat ingestion. J Clin Gastroenterol. 2015;49:165–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Péron JM, Bureau C, Poirson H, Mansuy JM, Alric L, Selves J, et al. Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. J Viral Hepat. 2007;14:298–303.CrossRefPubMedGoogle Scholar
  4. 4.
    Kamar N, Izopet J, Tripon S, Bismuth M, Hillaire S, Dumortier J, et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med. 2014;370:1111–20.CrossRefPubMedGoogle Scholar
  5. 5.
    Dao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D, et al. Sofosbuvir inhibits hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. 2016;150:82–5.CrossRefPubMedGoogle Scholar
  6. 6.
    Garbuglia AR, Scognamiglio P, Petrosillo N, Mastroianni CM, Sordillo P, Gentile D, et al. Hepatitis E virus genotype 4 outbreak, Italy, 2011. Emerg Infect Dis. 2013;19:110–4.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Donnelly MC, Imlach SN, Abravanel F, Ramalingam S, Johannessen I, Petrik J, et al. Sofosbuvir and daclatasvir anti-viral therapy fails to clear HEV viremia and restore reactive T cells in a HEV/HCV co-infected liver transplant recipient. Gastroenterology. 2017;152:300–1.CrossRefPubMedGoogle Scholar
  8. 8.
    Van der Valk M, Zaaijer HL, Kater AP, Schinkel J. Sofosbuvir shows antiviral activity in a patient with chronic hepatitis E virus infection. J Hepatol. 2017;66:242–3.CrossRefPubMedGoogle Scholar
  9. 9.
    Todesco E, Demeret S, Calin R, Roque-Afonso AM, Thibault V, Mallet V, et al. Chronic hepatitis E in HIV/HBV coinfected patient: lack of power of sofosbuvir-ribavirin. AIDS. 2017;31:1346–8.CrossRefPubMedGoogle Scholar
  10. 10.
    Pavio N, Doceul V, Bagdassarian E, Johne R. Recent knowledge on hepatitis E virus in Suidae reservoirs and transmission routes to human. Vet Res. 2017;48:78.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Elisa Biliotti
    • 1
  • Cristiana Franchi
    • 1
  • Martina Spaziante
    • 1
  • Anna Rosa Garbuglia
    • 2
  • Lorenzo Volpicelli
    • 1
  • Donatella Palazzo
    • 1
  • Maurizio De Angelis
    • 1
  • Rozenn Esvan
    • 1
  • Gloria Taliani
    • 1
  1. 1.Department of Clinical Medicine, Clinic of Tropical MedicineSapienza University of RomeRomeItaly
  2. 2.Laboratory of VirologyNational Institute for Infectious Diseases “Lazzaro Spallanzani”RomeItaly

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