Infection

, Volume 45, Issue 4, pp 533–537 | Cite as

Influence of molecular characteristics in the prognosis of methicillin-resistant Staphylococcus aureus prosthetic joint infections: beyond the species and the antibiogram

  • Irene Muñoz-Gallego
  • Jaime Lora-Tamayo
  • Dafne Pérez-Montarelo
  • Patricia Brañas
  • Esther Viedma
  • Fernando Chaves
Brief Report
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Accepted:

Abstract

We have explored the relationship of phenotypic (antibiogram, β-haemolysis, agr functionality, biofilm formation) and genotypic characteristics on the prognosis of 18 cases of methicillin-resistant S. aureus prosthetic joint infection (2005–2015). All isolates belonged to CC5, and had agr type II. This pilot study suggests that phage-borne genes belonging to the immune evasion cluster (chp, sak and scn) were more frequent among episodes with treatment failure (80.0 vs. 37.5%).

Keywords

Biofilms Bone infections Joint infections DAIR MRSA 
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Notes

Compliance with ethical standards

Funding

J.L-T holds a clinical research contract “Sara Borrell” (CD14/00176) from the Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness. This work was supported by the Fondo de Investigaciones Sanitarias (PI12/01205), Instituto de Salud Carlos III, Spain.

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Irene Muñoz-Gallego
    • 1
  • Jaime Lora-Tamayo
    • 2
  • Dafne Pérez-Montarelo
    • 1
  • Patricia Brañas
    • 1
  • Esther Viedma
    • 1
  • Fernando Chaves
    • 1
  1. 1.Servicio de Microbiología, Instituto de Investigación Biomédica Hospital 12 de OctubreHospital Universitario 12 de OctubreMadridSpain
  2. 2.Unidad de Enfermedades Infecciosas, Instituto de Investigación Biomédica Hospital 12 de OctubreHospital Universitario 12 de OctubreMadridSpain

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