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Infection

, Volume 45, Issue 1, pp 67–74 | Cite as

Predictive risk factors for Listeria monocytogenes meningitis compared to pneumococcal meningitis: a multicenter case–control study

  • Seungjin Lim
  • Doo Ryeon Chung
  • Yeon-Sook Kim
  • Kyung Mok Sohn
  • Seung-Ji Kang
  • Sook-In Jung
  • Shin-Woo Kim
  • Hyun Ha Chang
  • Seung Soon Lee
  • In-Gyu Bae
  • Chisook Moon
  • Ji-Young Rhee
  • Jin Seo Lee
  • Hyun Kyun Ki
  • Hyun Ah Kim
  • Seong Yeol Ryu
  • Joon-Sup Yeom
  • Jun Seong Son
  • Soo-youn Moon
  • Ki Tae Kwon
  • Hyuck Lee
  • Sang Taek Heo
  • Cheol-In Kang
  • Kyong Ran Peck
  • Jae-Hoon Song
Original Paper

Abstract

Purpose

Various immunocompromised conditions increase the risk of meningitis caused by Listeria monocytogenes. However, the relative importance of these risk factors has not been well established. We determined the risk factors that predict meningitis due to L. monocytogenes compared to that caused by Streptococcus pneumoniae.

Methods

A nationwide multicenter case–control study was conducted in Korea. Cases of meningitis caused by L. monocytogenes between 1998 and 2013 were included. Patients with pneumococcal meningitis were included as controls. Multivariate logistic regression analysis was used to predict the risk factors of Listeria meningitis.

Results

A total of 36 cases and 113 controls were enrolled. The most significant predictive risk factor of Listeria meningitis was a prior history of receiving immunosuppressive therapy (odds ratio 8.12, 95 % CI 2.47–26.69). Chronic liver disease was the second most important predictive risk factor (OR 5.03, 95 % CI 1.56–16.22). Delaying appropriate antibiotic therapy by more than 6 h (hazard ratio 2.78) and fatal underlying disease (hazard ratio 2.88) were associated with increased mortality.

Conclusions

Patients with a prior history of receiving immunosuppressive therapy within 1 month and chronic liver disease have 8.1-fold and 5-fold increased risk of meningitis by L. monocytogenes compared to S. pneumoniae, respectively.

Keywords

Immunocompromised host Liver diseases Elderly Streptococcus pneumoniae Listeriosis 

Notes

Acknowledgments

This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant No. HI12C0756).

Compliance with ethical standards

This study was approved by the Samsung Medical Center Institutional Review Board (2008-06-052-001).

Conflict of interest

All authors have nothing to declare.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Seungjin Lim
    • 1
    • 17
  • Doo Ryeon Chung
    • 1
  • Yeon-Sook Kim
    • 2
  • Kyung Mok Sohn
    • 2
  • Seung-Ji Kang
    • 3
  • Sook-In Jung
    • 3
  • Shin-Woo Kim
    • 4
  • Hyun Ha Chang
    • 4
  • Seung Soon Lee
    • 5
  • In-Gyu Bae
    • 6
  • Chisook Moon
    • 7
  • Ji-Young Rhee
    • 8
  • Jin Seo Lee
    • 9
  • Hyun Kyun Ki
    • 10
  • Hyun Ah Kim
    • 11
  • Seong Yeol Ryu
    • 11
  • Joon-Sup Yeom
    • 12
  • Jun Seong Son
    • 13
  • Soo-youn Moon
    • 13
  • Ki Tae Kwon
    • 14
  • Hyuck Lee
    • 15
  • Sang Taek Heo
    • 16
  • Cheol-In Kang
    • 1
  • Kyong Ran Peck
    • 1
  • Jae-Hoon Song
    • 1
  1. 1.Division of Infectious Diseases, Department of Internal MedicineSamsung Medical Center, Sungkyunkwan University School of MedicineSeoulKorea
  2. 2.Division of Infectious DiseasesChungnam National University School of MedicineDaejeonKorea
  3. 3.Division of Infectious DiseasesChonnam National University HospitalGwangjuKorea
  4. 4.Department of Internal MedicineKyungpook National University School of MedicineDaeguKorea
  5. 5.Division of Infectious DiseasesHallym University Sacred Heart HospitalAnyangKorea
  6. 6.Department of Internal MedicineGyeongsang National University School of MedicineJinjuKorea
  7. 7.Division of Infectious DiseasesInje University Busan Paik HospitalBusanKorea
  8. 8.Division of Infectious DiseasesDankook University HospitalCheonanKorea
  9. 9.Division of Infectious DiseasesKangdong Sacred Heart HospitalSeoulKorea
  10. 10.Division of Infectious DiseasesKonkuk University HospitalSeoulKorea
  11. 11.Division of Infectious DiseasesKeimyung University Dongsan Medical CenterDaeguKorea
  12. 12.Department of Internal Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea
  13. 13.Division of Infectious DiseasesKyung Hee University Hospital at GangdongSeoulKorea
  14. 14.Division of Infectious DiseasesDaegu Fatima HospitalDaeguKorea
  15. 15.Division of Infectious DiseasesDong-A University HospitalBusanKorea
  16. 16.Division of Infectious DiseasesJeju National University School of MedicineJejuKorea
  17. 17.Department of Internal MedicineDongnam Institution of Radiological and Medical SciencesBusanKorea

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