, Volume 44, Issue 4, pp 543–546 | Cite as

Listeria meningoencephalitis and anti-GQ1b antibody syndrome

  • A. Vergori
  • G. Masi
  • D. Donati
  • F. Ginanneschi
  • P. Annunziata
  • A. Cerase
  • M. Mencarelli
  • B. Rossetti
  • A. De Luca
  • G. Zanelli
Case Report


We report the first case of Listeria monocytogenes meningoencephalitis associated with anti-GQ1b antibody syndrome in an immunocompetent adult. A prompt diagnosis, made thanks to the multidisciplinary contribution, allowed a combined therapeutic approach leading to final favourable outcome, despite several intercurrent complications.


Listeria Meningoencephalitis Miller-Fisher syndrome Bickerstaff brainstem encephalitis Anti-GQ1b IgG antibody 


Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.


  1. 1.
    Shahrizalia N, Yuki N. Bickerstaff brainstem encephalitis and Fisher syndrome: anti-GQ1b antibody syndrome. J Neurol Neurosurg Psychiatry. 2013;84:576–83.CrossRefGoogle Scholar
  2. 2.
    Wakerley BR, Uncini A, Yuki N, GBS Classification Group. Guillain-Barrè and Miller Fisher syndromes—new diagnostic classification. Nat Rev Neurol. 2014;10:537–44.CrossRefPubMedGoogle Scholar
  3. 3.
    Brouwer MC, van de Beek D, Heckenberg SG, Spanjaard L, de Gans J. Community-acquired listeria monocytogenes meningitis in adults. Clin Infect Dis. 2006;43:1233–8.CrossRefPubMedGoogle Scholar
  4. 4.
    Bennett L. Listeria monocytogenes. In: Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases, vol. 207. 7th ed. Philadelphia: Churchill Livingstone; 2010. p. 2707–14.CrossRefGoogle Scholar
  5. 5.
    Armstrong RW, Fung PC. Brainstem encephalitis (rhombencephalitis) due to Listeria moncytogenes: case report and review. Clin Infect Dis. 1993;16:689–702.CrossRefPubMedGoogle Scholar
  6. 6.
    Koga M, Gilbert M, Li J, Koike S, Takahashi M, Furukawa K, Hirata K, Yuki N. Antecedent infections in Fisher syndrome: a common pathogenesis of molecular mimicry. Neurology. 2005;64:1605–11.CrossRefPubMedGoogle Scholar
  7. 7.
    Ito M, Kuwabara S, Odaka M, Misawa S, Koga M, Hirata K, Yuki N. Bickerstaff’s brainstem encephalitis and Fisher syndrome form a continuous spectrum: clinical analysis of 581 cases. J Neurol. 2008;255:674–82.CrossRefPubMedGoogle Scholar
  8. 8.
    Uldry PA, Kuntzer T, Bogousslavsky J, Regli F, Miklossy J, Bille J, Francioli P, Janzer R. Early symptoms and outcome of Listeria monocytogenes rhombencephalitis: 14 adult cases. J Neurol. 1993;240:235–42.CrossRefPubMedGoogle Scholar
  9. 9.
    Alper G, Knepper L, Kanal E. MR findings in Listerial Rhomboencephalitis. Am J Neuroradiol. 1996;17:593–6.PubMedGoogle Scholar
  10. 10.
    Mook-Kanamori BB, Fritz D, Brouwer MC, van der Ende A, van de Beek D. Intracerebral hemorrhages in adults with community associated bacterial meningitis in adults: should we reconsider anticoagulant therapy? PLoS One. 2012;7:e45271.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Moro A, Albino PH, Bresciani AP, Oliveira MV, Bertotti MM, Ferreira RM, Queiroz LP. Rhombencephalitis caused by Listeria monocytogenes with striking involvement of trigeminal nerve on MR imaging. Arq Neuropsiquiatr. 2011;69:568–9.CrossRefPubMedGoogle Scholar
  12. 12.
    Van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Coomunity-acquired bacterial meningitis in adults. N Engl J Med. 2006;354:44–53.CrossRefPubMedGoogle Scholar
  13. 13.
    Overell JR, Hsieh ST, Odaka M, Yuki N, Willison HJ. Treatment for Fisher syndrome, Bickerstaff’s brainstem encephalitis and related disorders. Cochrane Database Syst Rev. 2007;1:CD004761.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.University Division of Infectious Diseases, Department of Medical BiotechnologiesUniversity of SienaSienaItaly
  2. 2.Department of Medicine, Surgery and Neurosciences, Clinical Neuroimmunology UnitUniversity of SienaSienaItaly
  3. 3.Unit of Neuroimaging and NeurointerventionUniversity Hospital of SienaSienaItaly

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