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Infection

, Volume 44, Issue 4, pp 441–445 | Cite as

Corynebacterium diphtheriae in a free-roaming red fox: case report and historical review on diphtheria in animals

  • Andreas SingEmail author
  • Regina Konrad
  • Dominik M. Meinel
  • Norman Mauder
  • Ingo Schwabe
  • Reinhard Sting
Review

Abstract

Objectives

Corynebacterium diphtheriae, the classical causative agent of diphtheria, is considered to be nearly restricted to humans. Here we report the first finding of a non-toxigenic C. diphtheriae biovar belfanti strain in a free-roaming wild animal.

Methods

The strain obtained from the subcutis and mammary gland of a dead red fox (Vulpes vulpes) was characterized by biochemical and molecular methods including MALDI-TOF and Multi Locus Sequence Typing. Since C. diphtheriae infections of animals, usually with close contact to humans, are reported only very rarely, an intense review comprising also scientific literature from the beginning of the 20th century was performed.

Results

Besides the present case, only 11 previously reported C. diphtheriae animal infections could be verified using current scientific criteria.

Conclusions

Our report is the first on the isolation of C. diphtheriae from a wildlife animal without any previous human contact. In contrast, the very few unambiguous publications on C. diphtheriae in animals referred to livestock or pet animals with close human contact. C. diphtheriae carriage in animals has to be considered as an exceptionally rare event.

Keywords

Diphtheria Corynebacterium diphtheriae Zoonosis Wildlife Animals Historical review 

Notes

Acknowledgments

We thank Wolfgang Schmidt, Sabine Wolf, Jasmin Fräßdorf, Barbara Depner and Christine Hartberger for excellent technical assistance. The study was partly supported by the Bavarian State Ministry of Health and Care as well as by the German Federal Ministry of Health via the Robert Koch-Institute and its National Reference Laboratories Network (09-47, FKZ 1369-359 and FKZ 415).

Compliance with ethical standards

Conflict of interest

None.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Andreas Sing
    • 1
    • 2
    Email author
  • Regina Konrad
    • 1
    • 2
  • Dominik M. Meinel
    • 2
  • Norman Mauder
    • 3
  • Ingo Schwabe
    • 3
  • Reinhard Sting
    • 3
  1. 1.National Consiliary Laboratory for DiphtheriaBavarian Health and Food Safety AuthorityOberschleißheimGermany
  2. 2.Bavarian Health and Food Safety AuthorityOberschleißheimGermany
  3. 3.Chemical and Veterinary Investigations Office StuttgartFellbachGermany

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