Infection

, Volume 43, Issue 3, pp 267–276 | Cite as

The impact of sporotrichosis in HIV-infected patients: a systematic review

Review

Abstract

Sporotrichosis is a fungal infection of man and animals caused by Sporothrix complex. It usually presents as a lymphocutaneous form, but disseminated disease may occur. Given the paucity of data about HIV/AIDS and sporotrichosis co-infection, a systematic review of reported cases of HIV-associated sporotrichosis found via Pubmed (1984–2013) was done. A total of 39 papers were included, and 58 patients’ data analyzed. Thirty-three (56.9 %) cases were from Brazil and 18 (31 %) from the USA. Patients’ mean age was 37.8 ± 10.4 years; males predominated (84.5 %). The median CD4+ cell count was 97 cells/mm3. The most common clinical forms were disseminated and disseminated cutaneous with 33 (56.9 %) and 10 (17.5 %) patients, respectively. There was a correlation between CD4+ count and clinical categories (p = 0.002). Mortality was 30 % and there was a correlation between central nervous system involvement and death (p < 0.001).

Keywords

Sporotrichosis AIDS Neglected diseases HAART Systematic review 

Supplementary material

15010_2015_746_MOESM1_ESM.doc (50 kb)
Supplementary material 1 (DOC 49 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Instituto Nacional de Infectologia Evandro ChagasFundação Oswaldo CruzRio de JaneiroBrazil
  2. 2.Instituto Nacional de CardiologiaRio de JaneiroBrazil
  3. 3.Unigranrio, Adjunct Professor of Infectious DiseasesRio de JaneiroBrazil

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