, Volume 41, Issue 1, pp 159–166 | Cite as

Chlamydia trachomatis prevalence, genotype distribution and identification of the new Swedish variant in Southern Germany

  • N. Fieser
  • U. Simnacher
  • Y. Tausch
  • S. Werner-Belak
  • S. Ladenburger-Strauß
  • H. von Baum
  • U. Reischl
  • A. Essig
Clinical and Epidemiological Study



In Germany, reliable data about the prevalence of urogenital Chlamydia trachomatis infections, causative genotypes, as well as corresponding clinical, demographic and behavioural information are sparse. We, therefore, performed a prospective prevalence study including 1,003 sexually active volunteers of a Southern German city.


Study participants completed a standardised questionnaire and provided first void urine samples for analysis. Our screening strategy included the performance of two nucleic acid amplification tests with different target genes, enabling the detection of the new Swedish variant of C. trachomatis (nvCT). Direct genotyping of positive specimens was performed by sequence analysis of the ompA gene.

Results and Conclusion

The overall prevalence of C. trachomatis infection was 4.2 % in women and 4.6 % in men. A relatively high prevalence of 8.3 % was found in men older than 25 years. Never using condoms was an independent risk factor for infection. The most common symptom was discharge; however, 64.5 % of infected females and all of the infected men were asymptomatic, supporting the need for screening programmes. The most frequently encountered genotypes were E (46.5 %), F (20.9 %) and K (14.0 %). Since the nvCT was detected in one female student, this is one of the rare studies that reports on the molecular identification of nvCT apart from Sweden.


Chlamydia trachomatis Chlamydia screening Genotypes New variant of C. trachomatis (nvCT) STD 



We thank Eberhard Straube (Institute of Medical Microbiology, Friedrich Schiller University Jena) for providing the control DNA of the nvCT. Special thanks go to Cornelia Otto and Stephanie Kurz (Public Health Departments of Ulm and Neu-Ulm), Christine Meißle (Health Care School, University Hospital Ulm), Katja Schlaupitz (General Practice, Neu-Ulm), Alexander Rauh (German Armed Forces Hospital, Ulm) and Anne-Marie Albuszies (TÜV SÜD Life Service GmbH) for the recruitment of study participants and sample collection. We thank Corinna Foddis, Sonja Rothenberger, Carola Maier and Beate Wirths (Institute of Medical Microbiology and Hygiene, University Hospital Ulm) for their expert technical assistance.

Conflict of interest

This study was supported by Hain Life science and Roche Diagnostics who provided test kits and financial support in part.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • N. Fieser
    • 1
    • 2
  • U. Simnacher
    • 1
  • Y. Tausch
    • 1
  • S. Werner-Belak
    • 1
  • S. Ladenburger-Strauß
    • 3
  • H. von Baum
    • 1
  • U. Reischl
    • 4
  • A. Essig
    • 1
  1. 1.Institute of Medical Microbiology and HygieneUniversity Hospital UlmUlmGermany
  2. 2.Gaertner and Colleagues LaboratoriesRavensburgGermany
  3. 3.Gynaecological PracticeSendenGermany
  4. 4.Institute of Medical Microbiology and HygieneUniversity Hospital RegensburgRegensburgGermany

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