Advertisement

Infection

, 39:473 | Cite as

Staphylococcus simulans as an authentic pathogenic agent of osteoarticular infections

  • M. Mallet
  • C. Loiez
  • H. Melliez
  • Y. Yazdanpanah
  • E. Senneville
  • X. Lemaire
Brief Report

Abstract

Objectives

To evaluate the role of Staphylococcus simulans in bone and joint infections (BJI) and determine their main characteristics.

Methods

A search of the database of the microbiology laboratories of Lille hospital and Tourcoing hospital was performed. Only results from blood, bone, and orthopedic device cultures were taken into account for hospitalized patients between January 2004 and January 2009. We considered cases in which S. simulans was the only bacteria isolated in all of the patients’ biological samples with clinical and laboratory signs of infection. For patients with complete medical records, we recorded the clinical and epidemiological data.

Results

Six cases of BJI due to S. simulans were recorded, with five cases related to orthopedic devices infections. Three patients lived in rural areas. In four out of six patients, S. simulans was isolated in intraoperative biopsy material. In one patient, S. simulans grew in synovial fluid and in another in blood cultures only. The latter patient had a spondylodiscitis, and chronic foot ulcers due to gout disease were suspected to be the origin of the infection. All patients were healed after a mean follow up of 9 ± 3 months. Orthopedic devices were removed in four of the five patients concerned. The combination of rifampicin plus levofloxacin was used in four patients.

Conclusion

The present data suggest that, even though S. simulans remains rarely observed in clinical pathology, its role in osteoarticular infections, especially in the case of infected orthopedic devices, is not exceptional. As for the antibiotic treatment, the combination of rifampicin and levofloxacin seems to be an effective strategy according to our clinical results.

Keywords

Staphylococcus simulans Osteoarticular infection Treatment Orthopedic device 

Notes

Conflict of interest

No funding to declare. No conflict to declare.

References

  1. 1.
    Males BM, Bartholomew WR, Amsterdam D. Staphylococcus simulans septicemia in a patient with chronic osteomyelitis and pyarthrosis. J Clin Microbiol. 1985;21:255–7.PubMedGoogle Scholar
  2. 2.
    Razonable RR, Lewallen DG, Patel R, Osmon DR. Vertebral osteomyelitis and prosthetic joint infection due to Staphylococcus simulans. Mayo Clin Proc. 2001;76:1067–70.PubMedCrossRefGoogle Scholar
  3. 3.
    Sturgess I, Martin FC, Eykyn S. Pubic osteomyelitis caused by Staphylococcus simulans. Postgrad Med J. 1993;69:927–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Vallianou N, Evangelopoulos A, Makri P, Zacharias G, Stefanitsi P, Karachalios A, et al. Vertebral osteomyelitis and native valve endocarditis due to Staphylococcus simulans: a case report. J Med Case Rep. 2008;2:183.CrossRefGoogle Scholar
  5. 5.
    Senneville E, Savage C, Nallet I, Yazdanpanah Y, Giraud F, Migaud H, et al. Improved aero–anaerobe recovery from infected prosthetic joint samples taken from 72 patients and collected intraoperatively in Rosenow’s broth. Acta Orthop. 2006;77:120–4.PubMedCrossRefGoogle Scholar
  6. 6.
    Thorberg BM, Danielsson-Tham ML, Emanuelson U, Persson Waller K. Bovine subclinical mastitis caused by different types of coagulase-negative staphylococci. J Dairy Sci. 2009;92:4962–70.PubMedCrossRefGoogle Scholar
  7. 7.
    Penna B, Varges R, Medeiros L, Martins GM, Martins RR, Lilenbaum W. Species distribution and antimicrobial susceptibility of staphylococci isolated from canine otitis externa. Vet Dermatol. 2010;21:292–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Lilenbaum W, Esteves AL, Souza GN. Prevalence and antimicrobial susceptibility of staphylococci isolated from saliva of clinically normal cats. Lett Appl Microbiol. 1999;28:448–52.PubMedCrossRefGoogle Scholar
  9. 9.
    Kloos WE, Barnerman TL. Staphylococcus and Micrococcus. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, editors. Manual of clinical microbiology. 7th ed. ASM Press: Washington; 1999.Google Scholar
  10. 10.
    McCarthy JS, Stanley PA, Mayall B. A case of Staphylococcus simulans endocarditis affecting a native heart valve. J Infect. 1991;22:211–2.PubMedCrossRefGoogle Scholar
  11. 11.
    Ohshima Y, Schumacher-Perdreau F, Peters G, Pulverer G. The role of capsule as a barrier to bacteriophage adsorption in an encapsulated Staphylococcus simulans strain. Med Microbiol Immunol. 1988;177:229–33.PubMedGoogle Scholar
  12. 12.
    Dupont C, Sivadon-Tardy V, Bille E, Dauphin B, Beretti JL, Alvarez AS, et al. Identification of clinical coagulase-negative staphylococci, isolated in microbiology laboratories, by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and two automated systems. Clin Microbiol Infect. 2010;16:998–1004.PubMedGoogle Scholar
  13. 13.
    Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351:1645–54.PubMedCrossRefGoogle Scholar
  14. 14.
    Bindal M, Krabak B. Acute bacterial sacroiliitis in an adult: a case report and review of the literature. Arch Phys Med Rehabil. 2007;88:1357–9.PubMedCrossRefGoogle Scholar
  15. 15.
    El Samad Y, Havet E, Bentayeb H, Olory B, Canarelli B, Lardanchet JF, et al. Treatment of osteoarticular infections with clindamycin in adults. Med Mal Infect. 2008;38:465–70.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • M. Mallet
    • 1
  • C. Loiez
    • 2
  • H. Melliez
    • 1
  • Y. Yazdanpanah
    • 1
  • E. Senneville
    • 1
  • X. Lemaire
    • 1
    • 3
  1. 1.Infectious Diseases DepartmentDron HospitalTourcoingFrance
  2. 2.Bacteriology LaboratoryCHRU of LilleLilleFrance
  3. 3.Infectious Diseases and Internal MedicineCH DouaiDouaiFrance

Personalised recommendations