Lemierre syndrome caused by co-infection by Arcanobacterium haemolyticum and Fusobacterium necrophorum
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In 1936, Lemierre described a series of cases with anaerobic sepsis following primary oropharyngeal infection. These ‘postanginal septicemias’, subsequently denoted ‘Lemierre syndrome’ or ‘Lemierre’s disease’, were characterized by septic thrombophlebitis of the jugular venous system and multiple metastatic abscesses which were most commonly found in the lungs. The syndrome had a high case-fatality rate and affected mainly young adults . Although polymicrobial infections have been reported, the main pathogen in Lemierre syndrome is Fusobacterium necrophorum, an obligate anaerobic, Gram-negative rod . Disseminated infections are rare. The highest incidence occurs in the age group 15–24 years .
Arcanobacterium haemolyticum is an aerobic Gram-positive rod known to cause pharyngotonsillitis and skin rash, predominantly in adolescents and young adults [4, 5]. Deep-seated and systemic infections have been reported occasionally, and to the best of our knowledge only one case of...
KeywordsHuman Immunodeficiency Virus Sore Throat Blood Culture Bottle Fusobacterium Necrophorum Septic Thrombophlebitis
We acknowledge Dr. Prathap Solomon for radiological expertise.
Conflict of interest
- 2.Sinave CP, Hardy GJ, Fardy PW. The Lemierre syndrome: suppurative thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection. Medicine (Baltimore). 1989;68:85–94.Google Scholar