Infection

, 37:381 | Cite as

An influenza A H1N1 virus revival – pandemic H1N1/09 virus

Review

Abstract

In April 2009, a novel H1N1 influenza A virus, the so-called pandemic H1N1/09 virus (former designations include swine influenza, novel influenza, swine-origin influenza A [H1N1] virus [S-OIV], Mexican flu, North American Flu) was identified in Mexico. The virus has since spread throughout the world and caused an influenza pandemic as defined by the criteria of the World Health Organization. This represents the first influenza A virus pandemic since the emergence of H3N2 (‘‘Hong Kong’’ Flu) in 1968. Vaccine production has started, and vaccines are expected to become available during the course of 2009. Although the pandemic H1N1/09 virus originates from the triple-reassortant swine influenza (H1) virus circulating in North American pigs, it is not epidemic in pigs. Although the H1N1/09 virus pandemic is currently mild, concerns remain that it may become more aggressive during spreading. The distribution of proper information to the public on the status of the H1N1/09 virus pandemic will be important to achieve a broad awareness of the potential risks and the optimum code of behavior during the pandemic. Here, the features of pandemic H1N1/09 virus are discussed within the framework of knowledge gained from previous influenza A virus pandemics.

Keywords

Oseltamivir Seasonal Influenza Influenza Pandemic Zanamivir Oseltamivir Carboxylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Cinatl J Jr, Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part I: Epidemiologic concerns and virulence determinants. Med Microbiol Immunol 2007; 196: 181–190.CrossRefPubMedGoogle Scholar
  2. 2.
    Cinatl J Jr, Michaelis M, Doerr HW: The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology. Med Microbiol Immunol 2007; 196: 191–201.CrossRefPubMedGoogle Scholar
  3. 3.
    Cinatl J Jr, Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part III: Antiviral therapy. Med Microbiol Immunol 2007; 196: 203–212.CrossRefPubMedGoogle Scholar
  4. 4.
    Cinatl J Jr, Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part IV: Development of vaccines. Med Microbiol Immunol 2007; 196: 213–225.CrossRefPubMedGoogle Scholar
  5. 5.
    Michaelis M, Doerr HW, Cinatl J Jr: Of chickens and men: avian influenza in humans. Curr Mol Med 2009; 9: 131–151.CrossRefPubMedGoogle Scholar
  6. 6.
    Butler D: Swine flu goes global. Nature 2009; 458: 1082–1083.CrossRefPubMedGoogle Scholar
  7. 7.
    Scholtissek C, von Hoyningen V, Rott R: Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology 1978; 89: 613–617.CrossRefPubMedGoogle Scholar
  8. 8.
    Kilbourne ED: Influenza pandemics of the 20th century. Emerg Infect Dis 2006; 12: 9–14.PubMedGoogle Scholar
  9. 9.
    Nelson MI, Viboud C, Simonsen L, Bennett RT, Griesemer SB, St George K, Taylor J, Spiro DJ, Sengamalay NA, Ghedin E, Taubenberger JK, Holmes EC: Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathog 2008; 4: e1000012.CrossRefPubMedGoogle Scholar
  10. 10.
    Kilbourne ED, Smith C, Brett I, Pokorny BA, Johansson B, Cox N: The total influenza vaccine failure of 1947 revisited: major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic. Proc Natl Acad Sci USA 2002; 99: 10748–10752.CrossRefPubMedGoogle Scholar
  11. 11.
    Shope RE: The etiology of swine influenza. Science 1931; 73: 214–215.CrossRefPubMedGoogle Scholar
  12. 12.
    Shope RE: The incidence of neutralizing antibodies for swine influenza virus in the sera of human beings of different ages. J Exp Med 1936; 63: 669–684.CrossRefGoogle Scholar
  13. 13.
    Vana G, Westover KM: Origin of the 1918 Spanish influenza virus: a comparative genomic analysis. Mol Phylogenet Evol 2008; 47: 1100–1110.CrossRefPubMedGoogle Scholar
  14. 14.
    Smith GJ, Bahl J, Vijaykrishna D, Zhang J, Poon LL, Chen H, Webster RG, Peiris JS, Guan Y: Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci USA 2009; 106: 11709–11712.CrossRefPubMedGoogle Scholar
  15. 15.
    Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team: Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009; 360: 2605–2615.CrossRefGoogle Scholar
  16. 16.
    Shinde V, Bridges CB, Uyeki TM, Shu B, Balish A, Xu X, Lindstrom S, Gubareva LV, Deyde V, Garten RJ, Harris M, Gerber S, Vagoski S, Smith F, Pascoe N, Martin K, Dufficy D, Ritger K, Conover C, Quinlisk P, Klimov A, Bresee JS, Finelli L: Triple-reassortant swine influenza A (H1) in humans in the United States, 2005–2009. N Engl J Med 2009; 360: 2616–2625.CrossRefPubMedGoogle Scholar
  17. 17.
    Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y, Rambaut A: Origins, evolutionary genomics of the swine-origin H1N1 influenza A epidemic. Nature 2009; 2009: 1122–1125.CrossRefGoogle Scholar
  18. 18.
    Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y: In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 2009. doi: 10.1038/nature08260.Google Scholar
  19. 19.
    Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier RA, Pappas C, Alpuche-Aranda CM, López-Gatell H, Olivera H, López I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ: Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science 2009; 325: 197–201.CrossRefPubMedGoogle Scholar
  20. 20.
    Enserink M: Ferrets shed light on new virus’s severity and spread. Science 2009; 325: 17.CrossRefPubMedGoogle Scholar
  21. 21.
    Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA: Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis 2009; 9: 291–300.CrossRefPubMedGoogle Scholar
  22. 22.
    Carrat F, Vergu E, Ferguson NM, Lemaitre M, Cauchemez S, Leach S, Valleron AJ: Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 2008; 167: 775–785.CrossRefPubMedGoogle Scholar
  23. 23.
    Brankston G, Gitterman L, Hirji Z, Lemieux C, Gardam M: Transmission of influenza A in human beings. Lancet Infect Dis 2007; 7: 257–265.CrossRefPubMedGoogle Scholar
  24. 24.
    Tellier R: Review of aerosol transmission of influenza A virus. Emerg Infect Dis 2006; 12: 1657–1662.PubMedGoogle Scholar
  25. 25.
    Maines TR, Jayaraman A, Belser JA, Wadford DA, Pappas C, Zeng H, Gustin KM, Pearce MB, Viswanathan K, Shriver ZH, Raman R, Cox NJ, Sasisekharan R, Katz JM, Tumpey TM: Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science 2009; 2009: 484–487.Google Scholar
  26. 26.
    Munster VJ, de Wit E, van den Brand JM, Herfst S, Schrauwen EJ, Bestebroer TM, van de Vijver D, Boucher CA, Koopmans M, Rimmelzwaan GF, Kuiken T, Osterhaus AD, Fouchier RA: Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. Science 2009; 325: 481–483.PubMedGoogle Scholar
  27. 27.
    Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, Hollingsworth TD, Griffin J, Baggaley RF, Jenkins HE, Lyons EJ, Jombart T, Hinsley WR, Grassly NC, Balloux F, Ghani AC, Ferguson NM, Rambaut A, Pybus OG, Lopez-Gatell H, Apluche-Aranda CM, Chapela IB, Zavala EP, Guevara DM, Checchi F, Garcia E, Hugonnet S, Roth C: The WHO rapid pandemic assessment collaboration: pandemic potential of a strain of influenza A (H1N1): early findings. Science 2009; 324: 1557–1561.CrossRefPubMedGoogle Scholar
  28. 28.
    Jamieson DJ, Honein MA, Rasmussen SA, Williams JL, Swerdlow DL, Biggerstaff MS, Lindstrom S, Louie JK, Christ CM, Bohm SR, Fonseca VP, Ritger KA, Kuhles DJ, Eggers P, Bruce H, Davidson HA, Lutterloh E, Harris ML, Burke C, Cocoros N, Finelli L, Mac-Farlane KF, Shu B, Olsen SJ; Novel Influenza A (H1N1) Pregnancy Working Group: H1N1 2009 influenza virus infection during pregnancy in the USA. Lancet 2009; 374: 451–458.CrossRefPubMedGoogle Scholar
  29. 29.
    Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quiñones-Falconi F, Bautista E, Ramirez-Venegas A, Rojas-Serrano J, Ormsby CE, Corrales A, Higuera A, Mondragon E, Cordova-Villalobos JA: Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009; 361: 680–689.CrossRefPubMedGoogle Scholar
  30. 30.
    Murray CJ, Lopez AD, Chin B, Feehan D, Hill KH: Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis. Lancet 2006; 368: 2211–2218.CrossRefPubMedGoogle Scholar
  31. 31.
    Beck MA, Handy J, Levander OA: Host nutritional status: the neglected virulence factor. Trends Microbiol 2004; 12: 417–423.CrossRefPubMedGoogle Scholar
  32. 32.
    Morens DM, Taubenberger JK, Fauci AS: Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis 2008; 198: 962–970.CrossRefPubMedGoogle Scholar
  33. 33.
    Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O’Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW: A novel influenza A virus mitochondrial protein that induces cell death. Nat Med 2001; 7: 1306–1312.CrossRefPubMedGoogle Scholar
  34. 34.
    Cohen J: Swine flu outbreak. Past pandemics provide mixed clues to H1N1’s next moves. Science 2009; 324: 996–997.CrossRefPubMedGoogle Scholar
  35. 35.
    Allwinn R, Preiser W, Rabenau H, Buxbaum S, Stürmer M, Doerr HW: Laboratory diagnosis of influenza-virology or serology? Med Microbiol Immunol 2002; 191: 157–160.CrossRefPubMedGoogle Scholar
  36. 36.
    Centers for Disease Control and Prevention (CDC): Serum cross-reactive antibody response to a novel influenza A (H1N1) virus after vaccination with seasonal influenza vaccine. MMWR Morb Mortal Wkly Rep 2009; 58: 521–524.Google Scholar
  37. 37.
    De Groot AS, Ardito M, McClaine E, Moise L, Martin B: Immunoinformatic comparison of T-cell epitopes contained in novel swine-origin influenza A (H1N1) virus with epitopes in 2008–2009 conventional influenza vaccine. Vaccine 2009 [Epub ahead of print: 4 Aug].Google Scholar
  38. 38.
    Wattanagoon Y, Stepniewska K, Lindegårdh N, Pukrittayakamee S, Silachamroon U, Piyaphanee W, Singtoroj T, Hanpithakpong W, Davies G, Tarning J, Pongtavornpinyo W, Fukuda C, Singhasivanon P, Day NP, White NJ: Pharmacokinetics of high-dose oseltamivir in healthy volunteers. Antimicrob Agents Chemother 2009; 53: 945–952.CrossRefPubMedGoogle Scholar
  39. 39.
    Holodniy M, Penzak SR, Straight TM, Davey RT, Lee KK, Goetz MB, Raisch DW, Cunningham F, Lin ET, Olivo N, Deyton LR: Pharmacokinetics and tolerability of oseltamivir combined with probenecid. Antimicrob Agents Chemother 2008; 52: 3013–3021.CrossRefPubMedGoogle Scholar
  40. 40.
    Centers for Disease Control and Prevention (CDC): Update: influenza activity-United States, Septemper 28–November 29, 2008. MMWR Morb Mortal Wkly Rep 2008; 57: 1329–1332.Google Scholar
  41. 41.
    Moscona A: Global transmission of oseltamivir-resistant influenza. New Engl J Med 2008; 360: 953–956.CrossRefGoogle Scholar
  42. 42.
    Poland GA, Jacobson RM, Ovsyannikova IG: Influenza virus resistance to antiviral agents: a plea for rational use. Clin Infect Dis 2009; 48: 1254–1256.CrossRefPubMedGoogle Scholar
  43. 43.
    Centers for Disease Control and Prevention (CDC): Update: drug susceptibility of swine-origin influenza A (H1N1) viruses. MMWR Morb Mortal Wkly Rep 2009; 58: 433–435.Google Scholar
  44. 44.
    Enserink M: Hong Kong case suggests resistant swine flu may be spreading. ScienceInsider, 3 July 2009.Google Scholar
  45. 45.
    Bridges CB, Kuehnert MJ, Hall CB: Transmission of influenza: implications for control in health care settings. Clin Infect Dis 2003; 37: 1094–1101.CrossRefPubMedGoogle Scholar
  46. 46.
    Barry JM: Pandemics: avoiding the mistakes of 1918. Nature 2009; 459: 324–325.CrossRefPubMedGoogle Scholar
  47. 47.
    Sandman PM: Pandemics: good hygiene is not enough. Nature 2009; 459: 322–323.CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  1. 1.Institute for Medical VirologyJohann-Wolfgang-Goethe University ClinicFrankfurt am MainGermany

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