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Infection

, Volume 37, Issue 4, pp 340–343 | Cite as

Impact of Hepatitis B Vaccination in Children Born to HBsAg-Positive Mothers: a 20-year Retrospective Study

  • L. Bracciale
  • M. Fabbiani
  • A. Sansoni
  • L. Luzzi
  • L. Bernini
  • G. ZanelliEmail author
Clinical and Epidemiological Study

Abstract

Background:

Preventive measures remain the best approach to control the spread of hepatitis B virus (HBV) infection.

Patients and Methods:

To evaluate the effectiveness of vaccination against HBV, we conducted a 20-year retrospective study on 100 subjects, born to hepatitis B surface antigen (HBsAg)-positive mothers, who had received postexposure prophylaxis at the Clinic of Infectious Diseases (Siena University, Italy) during 1984–2004. All patients were tested for the presence of HBsAg, anti-HBs and anti-HB core antigen (anti-HBc).

Results:

Two subjects (2%) acquired the infection as shown by the presence of anti-HBc. Of the 98 patients who did not acquire the infection, 62 of these (63.3%) had an anti-HBs concentration considered protective (‡ 10 mIU/ml). The percentage of protected subjects decreased in relation to time from vaccination with a significant reduction (p = 0.009) of anti-HBs geometric mean titre (GMT) after 5 years, which reached the level of 10 mIU/ml after about 15 years. No patients without protective concentration have acquired the infection as of today. Only 12% of the HBsAgpositive mothers were followed in specialized structures after pregnancy, reflecting the scarce knowledge of the problem in the general population.

Conclusion:

Our data, while confirming the effectiveness of anti hepatitis B vaccination, highlight the need for postvaccination follow-up, particularly in high-risk categories, to prolong protection, through booster doses if necessary. We show, moreover, the importance of maintaining active surveillance in the territory to improve follow-up to chronic carriers and to sensitize families.

Keywords

Acute Hepatitis Booster Dose Postexposure Prophylaxis Vaccination Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2009

Authors and Affiliations

  • L. Bracciale
    • 1
  • M. Fabbiani
    • 1
  • A. Sansoni
    • 1
  • L. Luzzi
    • 1
  • L. Bernini
    • 1
  • G. Zanelli
    • 1
    Email author
  1. 1.Infectious Diseases ClinicDept. of Molecular Biology, Siena UniversitySienaItaly

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