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Infection

, Volume 36, Issue 2, pp 130–134 | Cite as

Immunity to Varicella Zoster Virus Among Young Adults: A Decline Prior to Widespread Uptake of Varicella Vaccines

  • I. Grotto
  • R. D. Balicer
  • Z. Smetana
  • N. Davidovitch
  • Y. Bar-Zeev
  • E. Mendelson
  • S. Zarka
  • M. Huerta
Clinical and Epidemiological Study

Abstract

Background:

The epidemiology of chickenpox in Israel is changing, mainly due to the increasing – but not universal – uptake of varicella vaccine.

Patients and Methods:

We conducted a seroprevalence study of varicella zoster virus (VZV) antibodies among 536 Israeli military recruits 18 years of age, on the basis of a representative sample of sera collected in 2003.

Results:

The overall seroprevalence rate was 94.6%, which was significantly lower than that observed in a similar population in 1992 (98.4%, p < 0.001). The rate was lower among subjects whose fathers had less than 12 years of schooling (89.8%, p = 0.033). No statistically significant differences were observed when data were stratified by sex, subject's level of education, or origin.

Conclusion:

This decline in the level of immunity must be considered when determining pre- and post-exposure vaccination policy among young adults in crowded environments.

Keywords

Chickenpox Measle Vaccine Varicella Vaccine Seroprevalence Rate Geometric Mean Titer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Urban & Vogel München 2008

Authors and Affiliations

  • I. Grotto
    • 1
    • 5
  • R. D. Balicer
    • 1
    • 2
  • Z. Smetana
    • 3
  • N. Davidovitch
    • 1
  • Y. Bar-Zeev
    • 2
  • E. Mendelson
    • 3
  • S. Zarka
    • 4
  • M. Huerta
    • 1
    • 2
  1. 1.Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael
  2. 2.Army Health BranchIsrael Defense Force Military Corps, Military PostIsrael
  3. 3.Central Virology LaboratoryMinistry of Health, Sheba Medical CenterTel-HashomerIsrael
  4. 4.School of Public HealthUniversity of HaifaHaifaIsrael
  5. 5.Epidemiology Department, Faculty of Health SciencesBen-Gurion University if the NegevBeer-ShevaIsrael

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