Infection

, Volume 36, Issue 2, pp 130–134

Immunity to Varicella Zoster Virus Among Young Adults: A Decline Prior to Widespread Uptake of Varicella Vaccines

  • I. Grotto
  • R. D. Balicer
  • Z. Smetana
  • N. Davidovitch
  • Y. Bar-Zeev
  • E. Mendelson
  • S. Zarka
  • M. Huerta
Clinical and Epidemiological Study

DOI: 10.1007/s15010-007-7192-7

Cite this article as:
Grotto, I., Balicer, R.D., Smetana, Z. et al. Infection (2008) 36: 130. doi:10.1007/s15010-007-7192-7

Abstract

Background:

The epidemiology of chickenpox in Israel is changing, mainly due to the increasing – but not universal – uptake of varicella vaccine.

Patients and Methods:

We conducted a seroprevalence study of varicella zoster virus (VZV) antibodies among 536 Israeli military recruits 18 years of age, on the basis of a representative sample of sera collected in 2003.

Results:

The overall seroprevalence rate was 94.6%, which was significantly lower than that observed in a similar population in 1992 (98.4%, p < 0.001). The rate was lower among subjects whose fathers had less than 12 years of schooling (89.8%, p = 0.033). No statistically significant differences were observed when data were stratified by sex, subject's level of education, or origin.

Conclusion:

This decline in the level of immunity must be considered when determining pre- and post-exposure vaccination policy among young adults in crowded environments.

Copyright information

© Urban & Vogel München 2008

Authors and Affiliations

  • I. Grotto
    • 1
    • 5
  • R. D. Balicer
    • 1
    • 2
  • Z. Smetana
    • 3
  • N. Davidovitch
    • 1
  • Y. Bar-Zeev
    • 2
  • E. Mendelson
    • 3
  • S. Zarka
    • 4
  • M. Huerta
    • 1
    • 2
  1. 1.Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael
  2. 2.Army Health BranchIsrael Defense Force Military Corps, Military PostIsrael
  3. 3.Central Virology LaboratoryMinistry of Health, Sheba Medical CenterTel-HashomerIsrael
  4. 4.School of Public HealthUniversity of HaifaHaifaIsrael
  5. 5.Epidemiology Department, Faculty of Health SciencesBen-Gurion University if the NegevBeer-ShevaIsrael

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