, Volume 33, Issue 3, pp 160–162 | Cite as

Susceptibility to HIV/AIDS: An Individual Characteristic We Can Measure?

  • B. Jülg
  • F. D. GoebelEmail author

Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could now be possible. In a recent study, a significant interindividual and interpopulation difference in the copy number of a segmental duplication encompassing the gene encoding CCL3L1, a potent human immunodeficiency virus-1 (HIV- 1)-suppressive chemokine was found. Possession of a CCL3L1 copy number lower than the population average was associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/ AIDS, potentially enabling clinicians to adapt treatment regimens. Also, this is particularly important for assessment of the efficacy of a protective vaccine.


Treatment Regimen Family Medicine Individual Characteristic Population Average Screen Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Urban & Vogel Medien und Medizin Verlagsgesellschaft 2005

Authors and Affiliations

  1. 1.Dept. of Infectious Diseases, Medical PoliclinicLudwig Maximilian University MunichMunichGermany

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