Advertisement

Infection

, Volume 33, Issue 4, pp 264–266 | Cite as

Cerebrospinal Fluid Adenosine Deaminase Levels and Adverse Neurological Outcome in Pediatric Tuberculous Meningitis

Clinical and Epidemiological Study

Abstract

Background:

There is a lack of data on the prognostic significance of changes in cerebrospinal fluid (CSF) parameters in tuberculous meningitis. Our objective was to determine whether changes in CSF parameters are associated with poor neurological outcome in tuberculous meningitis.

Patients and Methods:

We conducted a prospective cohort study on children admitted with a diagnosis of tuberculous meningitis to Government General Hospital in Kakinada, India. On admission, CSF parameters including cell count with fraction of lymphocytes and neutrophil leukocytes, glucose, protein, lactic dehydrogenase (LDH), and adenosine deaminase (ADA) levels were measured. We compared levels in children with and without adverse neurological outcome.

Results:

A total of 26 children was enrolled over a 2–year period. Ten had an adverse neurological outcome. Six had permanent neurological deficits (four hemiplegia and two cranial nerve palsies), two a hydrocephalus and two died. There was no significant (p > 0.05) difference in age, gender and in CSF parameters, including cell count, lymphocyte and neutrophil leukocyte fraction, glucose, protein, and LDH levels between patients with and without adverse neurological outcome. Patients with adverse outcome had with a mean (SD) of 17.1 (3.2) IU/l a significantly higher ADA level than patients without, who had a mean (SD) level of 11.3 (2.7) IU/l (p < 0.001, t–test).

Conclusion:

Adverse neurological outcome in childhood tuberculous meningitis is associated with increased cerebrospinal fluid adenosine deaminase levels.

Keywords

Hydrocephalus Nerve Palsy Neurological Outcome Adenosine Deaminase Hemiplegia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Urban & Vogel München 2005

Authors and Affiliations

  • S. Jakka
    • 1
  • S. Veena
    • 2
  • A. R. M. Rao
    • 2
  • M. Eisenhut
    • 3
  1. 1.Hinchingbrooke HospitalHuntingdonUK
  2. 2.Government General HospitalKakinadaIndia
  3. 3.Liverpool L14 2EDUK

Personalised recommendations