, Volume 33, Issue 3, pp 155–157 | Cite as

Linezolid Contributed to Clostridium difficile Colitis with Fatal Outcome

  • L. T. ZabelEmail author
  • S. Worm
Case Report


Linezolid, the first of a new class of antibacterial drugs, the oxazolidinones, has inhibitory activity against a broad range of gram-positive aerobic cocci and also against certain anaerobes. Although diarrhea is one of the most frequently encountered adverse effects of linezolid, Clostridium difficile-related complications are very uncommon. One case of fatal C. difficile colitis in a patient with spondylodiscitis, who had received a long-term course of linezolid therapy, is presented. Colitis was able to be exclusively assigned to linezolid. Factors contributing to the colitis are discussed.


Public Health Adverse Effect Internal Medicine Infectious Disease Diarrhea 
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Copyright information

© Urban & Vogel Medien und Medizin Verlagsgesellschaft 2005

Authors and Affiliations

  1. 1.Institut für LaboratoriumsmedizinKlinik am EichertGöppingenGermany
  2. 2.Unfallchirurgische KlinikKlinik am EichertGöppingenGermany

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