Infection

, Volume 30, Issue 5, pp 293–298 | Cite as

Lipodystrophy Syndrome by HAART in HIV-Infected Patients: Manifestation, Mechanisms and Management

  • H. H. Hirsch
  • M. Battegay
Review

Abstract.

Progressive changes in the distributions of body fat and severe alterations of lipid, glucose and lactate levels challenge the mid and long-term success of highly active antiretroviral therapy of HIV-infection. Both clinical diagnosis of the lipodystrophy syndrome and scientific elucidation of the underlying mechanisms may benefit from a working case definition. In this article, pathophysiological and therapeutic aspects are discussed with reference to physical and metaboloic changes. Checkpoints for a practical approach to the patient at risk are given. Specific care and management depend on th epredominant alteration, the stage of HIV disease and the medical and antiretroviral history of the individual patient.

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Copyright information

© Urban & Vogel Medien und Medizin Verlagsgesellschaft 2002

Authors and Affiliations

  • H. H. Hirsch
    • 1
  • M. Battegay
    • 1
  1. 1.Division of Infectious Diseases, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. mbattegay@uhbs.chCH

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