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Allergo Journal

, Volume 27, Issue 7, pp 32–37 | Cite as

Local bivalve allergens — a Malaysian perspective

  • Zailatul Hani Mohamad Yadzir
  • Misnan Rosmilah
  • Faizal Bakhtiar
  • Syakirah Samsudin
  • Noormalin Abdullah
Übersicht
  • 8 Downloads

Abstract

Background

Apart from the nutritional benefits, bivalves are also considered to be among a group of allergenic foods. Symptoms of allergy to bivalves are largely similar to those of allergic reactions reported for other shellfish. The identification of allergenic proteins in a particular species is an important step for the development of more accurate allergy tests and for the definition of more effective management of patients. Currently, studies regarding the allergens in bivalve species are lacking.

Materials and methods

This minireview is an overview of local scientific articles on identification of bivalve allergens by allergenomics methods including sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional gel electrophoresis (2-DE), immunoblotting and mass-spectrometry analysis.

Results

Tropomyosin has been the only well recognized allergen in a wide range of bivalve species. In addition to tropomyosin, our local study resulted in discovery of three novel bivalve major allergens; arginine kinase (40 kDa), actin (42 kDa) and troponin C (18 kDa).

Conclusion

This minireview will provide a better understanding of each allergen derived from local bivalves which subsequently will help in the understanding of the specific immunoglobulin E(IgE)-mediated immune response.

Schlüsselwörter

allergen bivalve tropomyosin arginine kinase actin troponin C mollusca 

Abbreviations

2-DE

Two dimensional-gel electrophoresis

cDNA

Complementary deoxyribonucleic acid

ELISA

Enzyme-linked immunosorbent assay

SDS-PAGE

Sodium dodecyl sulfate polyacrylamide-gel electrophoresis

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Copyright information

© Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Zailatul Hani Mohamad Yadzir
    • 1
  • Misnan Rosmilah
    • 2
  • Faizal Bakhtiar
    • 1
  • Syakirah Samsudin
    • 2
  • Noormalin Abdullah
    • 1
  1. 1.Allergy and Immunology Research CentreInstitute for Medical ResearchKuala LumpurMalaysia
  2. 2.Department of Biology, Faculty of Science and MathematicsUniversiti Pendidikan Sultan IdrisTanjong MalimMalaysia

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