Allergo Journal

, Volume 22, Issue 8, pp 559–561

Tick bite induced IgE antibodies to alpha-gal and delayed anaphylactic reactions to mammalian derived foods

  • Thomas A. E. Platts-Mills
  • Scotttt P. Commins
Short Communication_Kurzbeitrag

Key words

Anaphylaxis tick bites IgE to alpha-gal delayed reaction to red meat 





Galactose alpha-1, 3-galactose


Cross reactive carbohydrate determinants


Complementarity determining regions


Fragment, antigen binding




Low density Lipoprotein


Very low density Lipoprotein

Zeckenbiss induzierte IgE-Antikörper gegen alpha-Gal und verzögerte anaphylaktische Reaktionen auf aus Säugetieren gewonnenen Nahrungsmitteln


Anaphylaxie Zeckenbiss IgE gegen alpha-Gal verzögerte Reaktion auf rotes Fleisch 


  1. 1.
    O’Neil BH, Allen R, Spigel DR, Stinchcombe TE, Moore DT, Berlin JD et al. High incidence of cetuximab-related infusion reactions in Tennessee and North Carolina and the association with atopic history. J Clin Oncol 2007; 25: 3644–8CrossRefPubMedGoogle Scholar
  2. 2.
    Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N Engl J Med 2008; 358: 1109–17CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Milland J, Sandrin MS. ABO blood group and related antigens, natural antibodies and transplantation. Tissue Antigens 2006; 68: 459–66CrossRefPubMedGoogle Scholar
  4. 4.
    Commins SP, Satinover SM, Hosen J, Mozena J, Borish L, Lewis BD et al. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2009; 123: 426–33CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Grönlund H, Adédoyin J, Commins SP, Platts-Mills TA, van Hage M. The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA. J Allergy Clin Immunol 2009; 123: 1189–91CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Commins SP, Kelly LA, Rönmark E, James HR, Pochan SL, Peters EJ et al. Galactose-alpha-1,3-Galactose-Specific IgE is associated with anaphylaxis but not asthma. Am J Respir Crit Care Med 2012; 185: 723–30CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. JACI 2011; 127: 1286–93Google Scholar
  8. 8.
    Morisset M, Richard C, Astier C, Jacquenet S, Croizier A, Beaudouin E et al. Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose. Allergy 2012; 67: 699–7CrossRefPubMedGoogle Scholar

Copyright information

© Urban & Vogel GmbH 2013

Authors and Affiliations

  • Thomas A. E. Platts-Mills
    • 1
    • 2
  • Scotttt P. Commins
    • 1
  1. 1.Asthma and Allergic Disease CenterUniversity of VirginiaCharlottesvilleUSA
  2. 2.University of VirginiaCharlottesvilleUSA

Personalised recommendations