Allergo Journal

, Volume 21, Issue 8, pp 479–485

Allergie und atopische Dermatitis — ausgewählte Aspekte aus Klinik und Forschung

Übersicht Review Article

Zusammenfassung

Allergene stellen mögliche Triggerfaktoren der atopischen Dermatitis dar. Der relative Stellenwert für den klinischen Verlauf wird jedoch nach wie vor kontrovers diskutiert. Insbesondere die seit einigen Jahren sprunghaft angestiegenen Erkenntnisse zu Barrieredefekten in der Haut schienen das Konzept der allergengetriebenen atopischen Dermatitis zunächst infrage zu stellen. In dieser kurzen Übersicht werden einige ausgewählte Aspekte zur Rolle von Allergien bei Neurodermitis dargestellt. Neben klassischen Allergenen werden dabei auch mikrobielle Antigene und Autoantigene als potenzielle Allergene angesprochen. Andere Triggerfaktoren wie Klima, irritierende Substanzen oder hormonelle Faktoren können die allergische Immunantwort bei atopischer Dermatitis grundsätzlich ebenfalls beeinflussen, stehen jedoch nicht im Fokus dieses Artikels.

Schlüsselwörter

Atopische Dermatitis atopisches Ekzem Neurodermitis spezifisches IgE T-Lymphozyten Nahrungsmittelallergie Autoallergie mikrobielle Allergene spezifische Immuntherapie Histamin-4-Rezeptor 

Verwendete Abkürzungen

AWMF

Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften

IgE

Immunglobulin E

IL

Interleukin

SCORAD

Scoring Atopic Dermatitis der European Task Force on Atopic Dermatitis

TH2

Typ-2-T-Helferzellen

Allergy and atopic dermatitis Selected aspects of clinical management and research

Summary

Allergens are possible trigger factors of atopic dermatitis. The clinical importance of allergens as trigger factors of atopic dermatitis is still a matter of debate. The increase of knowledge of molecular mechanism of barrier defects in atopic dermatitis during the last years led to a challenge of the concept of allergen-driven atopic dermatitis. This short review summarizes selected aspects of the role of allergens in atopic dermatitis. In addition to „classical“ allergens microbial antigens and autoantigens as potential allergens are also discussed in atopic dermatitis. Other trigger factors like climate, skin irritants or hormones can influence the allergic immune response in atopic dermatitis but are not focussed in this paper.

Key words

Atopic dermatitis atopic eczema specific IgE Tlymphocytes food allergy autoallergy microbial allergens specific immunotherapy histamine H4 receptor 

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Copyright information

© Urban & Vogel 2012

Authors and Affiliations

  1. 1.Klinik für Dermatologie, Allergologie und VenerologieMedizinische Hochschule Hannover (MHH)HannoverDeutschland

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