Perspective on Intra-articular Injection Cell Therapy for Osteoarthritis Treatment

  • Gun-Il ImEmail author
Review Article
Part of the following topical collections:
  1. Cartilage regeneration
  2. Cartilage regeneration



Osteoarthritis (OA), the most common arthritis, is one of the most frequently encountered orthopaedic conditions. As a small number of large joints such as knee and hip are affected in OA, OA is an ideal target for local therapy. Although corticosteroid and hyaluronic acid have been traditionally used for joints through intra-articular (IA) injection, IA injection also provides a minimally invasive route to apply cell therapy to treat OA. IA cell therapy has drawn attention because it may provide regeneration of articular cartilage in addition to palliative anti-inflammatory effects.


Current progress of IA injection therapy and the author’s perspective on this issue are described narratively.


It is too premature to have any conclusion on the eventual efficacy of IA cell therapy concerning regeneration of articular cartilage based on current data. Prospective radiological and histological data from larger numbers of patients are needed to prove cost effectiveness of IA cell therapy.


Expanding research in this field will produce further evidences to provide guidance on the eventual effectiveness of IA cell therapy in the future.


Cell therapy Intra-articular injection Cartilage regeneration Osteoarthritis treatment 



This study was supported by a research Grant (2017M3A9B4064777) from the National Research Foundation of Korea.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

There are no animal experiments carried out for this article.


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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Research Institute for Integrative Regenerative Biomedical EngineeringDongguk UniversityGoyangRepublic of Korea

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