Tissue Engineering and Regenerative Medicine

, Volume 14, Issue 6, pp 735–742 | Cite as

Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies

  • Shariq Najeeb
  • Zohaib Khurshid
  • Muhammad Atif Saleem Agwan
  • Shazia Akhbar Ansari
  • Muhammad Sohail Zafar
  • Jukka Pekka Matinlinna
Review Article


Platelet-rich fibrin (PRF) has been used in regenerative medicine and dentistry. Recently, its use has been advocated for regenerative periodontics and wound healing. The randomized control trials have assessed the regenerative efficacy of the PRF for restoring intrabony periodontal defects. The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: ‘platelet-rich fibrin’, ‘intrabony’, ‘periodontal’, ‘bone defect’ and ‘guided tissue regeneration’. A secondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being included. In majority of studies, PRF resulted in better clinical/radiographic outcomes than open flap debridement and augmented therapeutic effects of bone grafts. The combination of bovine bone substitutes and PRF resulted in better performance compared to alone. Similarly better outcomes were observed while using PRF in combination with nanohydroxyapatite, metformin and demineralized freeze-dried bone allograft. It can be concluded that PRF produces better outcomes than open flap debridement alone and augments the regenerative effects of bone substitutes.


Fibrin Intrabony defects Tissue engineering Regeneration Periodontal 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical statement

There are no animal experiments carried out for this article.


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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Shariq Najeeb
    • 1
  • Zohaib Khurshid
    • 2
  • Muhammad Atif Saleem Agwan
    • 3
  • Shazia Akhbar Ansari
    • 4
  • Muhammad Sohail Zafar
    • 5
    • 6
  • Jukka Pekka Matinlinna
    • 7
  1. 1.Restorative Dental Sciences DepartmentAl-Farabi CollegesRiyadhSaudi Arabia
  2. 2.Biomedical EngineeringThe University of Western OntarioLondonCanada
  3. 3.Department of Restorative Dentistry, College of DentistryQassim UniversityBuraidahSaudi Arabia
  4. 4.Department of Oral Microbiology, Dow Dental CollegeDow University of Health SciencesKarachiPakistan
  5. 5.Department of Restorative Dentistry, College of DentistryTaibah UniversityAl Madinah Al MunawwarahSaudi Arabia
  6. 6.Department of Dental Materials, Islamic International Dental CollegeRiphah International UniversityIslamabadPakistan
  7. 7.Department of Dental Materials Science, Faculty of DentistryThe University of Hong Kong, Prince Philip Dental HospitalPokfulamHong Kong

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