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Tissue Engineering and Regenerative Medicine

, Volume 13, Issue 5, pp 447–454 | Cite as

Efficient biomaterials for tissue engineering of female reproductive organs

  • Amin Tamadon
  • Kyu-Hyung Park
  • Yoon Young Kim
  • Byeong-Cheol Kang
  • Seung-Yup KuEmail author
Feature Article Tissue Engineering

Abstract

Current investigations on the bioengineering of female reproductive tissues have created new hopes for the women suffering from reproductive organ failure including congenital anomaly of the female reproductive tract or serious injuries. There are many surgically restore forms that constitute congenital anomaly, however, to date, there is no treatment except surgical treatment of transplantation for patients who are suffering from anomaly or dysfunction organs like vagina and uterus. Restoring and maintaining the normal function of ovary and uterus require the establishment of biological substitutes that can cover the roles of structural support for cells and passage of secreting molecules. As in the case of constructing other functional organs, reproductive organ manufacturing also needs biological matrices which can provide an appropriate condition for attachment, growth, proliferation and signaling of various kinds of grafted cells. Among the organs, uterus needs special features such as plasticity due to their amazing changes in volume when they are in the state of pregnancy. Although numerous natural and synthetic biomaterials are still at the experimental stage, some biomaterials have already been evaluated their efficacy for the reconstruction of female reproductive tissues. In this review, all the biomaterials cited in recent literature that have ever been used and that have a potential for the tissue engineering of female reproductive organs were reviewed, especially focused on bioengineered ovary and uterus.

Key Words

Tissue engineering Biomaterial Ovary Uterus 

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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Amin Tamadon
    • 1
  • Kyu-Hyung Park
    • 1
  • Yoon Young Kim
    • 2
  • Byeong-Cheol Kang
    • 3
    • 4
  • Seung-Yup Ku
    • 1
    Email author
  1. 1.Department of Obstetrics and GynecologySeoul National University College of MedicineSeoulKorea
  2. 2.Biomedical Research InstituteSeoul National University HospitalSeoulKorea
  3. 3.Department of Experimental Animal Research, Biomedical Research InstituteSeoul National University HospitalSeoulKorea
  4. 4.Graduate School of Translational MedicineSeoul National University College of MedicineSeoulKorea

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