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Tissue Engineering and Regenerative Medicine

, Volume 14, Issue 1, pp 1–14 | Cite as

Artificial Bone via Bone Tissue Engineering: Current Scenario and Challenges

  • Shivaji Kashte
  • Amit Kumar Jaiswal
  • Sachin Kadam
Review Article

Abstract

Bone provides mechanical support, and flexibility to the body as a structural frame work along with mineral storage, homeostasis, and blood pH regulation. The repair and/or replacement of injured or defective bone with healthy bone or bone substitute is a critical problem in orthopedic treatment. Recent advances in tissue engineering have shown promising results in developing bone material capable of substituting the conventional autogenic or allogenic bone transplants. In the present review, we have discussed natural and synthetic scaffold materials such as metal and metal alloys, ceramics, polymers, etc. which are widely being used along with their cellular counterparts such as stem cells in bone tissue engineering with their pros and cons.

Keywords

Bone Bone tissue engineering Scaffolds Growth factors Regenerative medicine 

Notes

Acknowledgements

Author would like to acknowledge University Grant Commission (UGC), Government of India, New Delhi for doctoral fellowship to Mr. Shivaji Kashte.

Compliance with ethical standards

Conflicts of interest

Authors have no potential conflicts of interest.

Ethical Statement

There are no animal experiments carried out for this article.

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Copyright information

© The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Shivaji Kashte
    • 1
    • 3
  • Amit Kumar Jaiswal
    • 2
  • Sachin Kadam
    • 3
  1. 1.Department of Biosciences and TechnologyDefence Institute of Advanced TechnologyGirinagar, PuneIndia
  2. 2.Center for Biomaterials, Cellular and Molecular TheranosticsVIT UniversityVelloreIndia
  3. 3.Center for Interdisciplinary ResearchD. Y. Patil UniversityKolhapurIndia

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