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Applied Biological Chemistry

, Volume 60, Issue 4, pp 411–418 | Cite as

Pharmacological effect of Rubus ulmifolius Schott as antihyperglycemic and antihyperlipidemic on streptozotocin (STZ)-induced albino mice

  • Khalil Akhtar
  • Syed Wadood Ali Shah
  • Assar Ali Shah
  • Muhammad Shoaib
  • Syed Kashif Haleem
  • Nighat Sultana
Article

Abstract

The aim of present study was to evaluate the antihyperglycemic and antihyperlipidemic effects of aerial parts of Rubus ulmifolius Schott on streptozotocin (STZ)-induced diabetic albino mice. A total of 48-, 60-day-old either sex (male and female) albino mice were treated with, normal control; 2% Tween-80 suspension (diabetic control); glibenclamide (500 μg/kg/orally); RU methanol extract (150 mg/kg/orally) (RUCrd1); RU methanol extract (300 mg/kg/orally) (RUCrd2); RU chloroform extract (150 mg/kg/orally) (RUC); RU ethyl acetate extract (150 mg/kg/orally) (RUE); and RU butanol extract (150 mg/kg/orally) (RUB) for a period of 15 days. Diabetes was induced in albino mice by single intraperitoneal injection of streptozotocin (50 mg/kg/b/w). After 15 days, group treated with glibenclamide, RUCrd1, RUCrd2, RUC, RUE and RUB exhibited a significant (P > 0.05) decrease in blood glucose level as compared to diabetic control groups. The total cholesterol, triglycerides and low-density lipoproteins as well as serum creatinine level, serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase and alkaline phosphatase were also significantly (P > 0.05) decreased in glibenclamide, RUCrd1, RUCrd2, RUC, RUE and RUB groups albino mice as compared to diabetic control. It was concluded that Rubus ulmifolius Schott extract has positive effect as hypoglycemic and antihyperlipidemic on diabetic albino mice.

Keywords

Albino mice Antihyperlipidemia Antihyperglycemic Rubus ulmifolius Schott Diabetes mellitus 

Abbreviations

LDL

Low-density lipoproteins

HDL

High-density lipoproteins

TGs

Triglycerides

ALP

Serum alkaline phosphatase

SGPT

Serum glutamate pyruvate transaminase

SGOT

Serum glutamate oxaloacetate transaminase

STZ

Streptozotocin

Notes

Acknowledgments

This is a self-funded study, not supported by any organization or any other funding source. We are grateful to Professor Dr Jehandar Shah, Ex Vice Chancellor Shaheed Benazir Bhutto University, Sheringal, Dir Upper (Taxonomist), who helped with the identification of the plant.

Compliance with ethical standards

Conflict of interest

The authors declared that they have no conflict of interest.

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Copyright information

© The Korean Society for Applied Biological Chemistry 2017

Authors and Affiliations

  • Khalil Akhtar
    • 1
  • Syed Wadood Ali Shah
    • 2
  • Assar Ali Shah
    • 3
  • Muhammad Shoaib
    • 2
  • Syed Kashif Haleem
    • 4
  • Nighat Sultana
    • 1
  1. 1.Department of BiochemistryHazara University MansehraMansehraPakistan
  2. 2.Department of MicrobiologyHazara University MansehraMansehraPakistan
  3. 3.College of Animal Sciences and TechnologyNanjing Agricultural UniversityNanjingPeople’s Republic of China
  4. 4.Department of PharmacyUniversity of MalakandLower DirPakistan

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