Molecular dynamics simulation of a psychrophilic adenylate kinase

  • Euiyoung Bae
  • Sojin Moon
  • George N. PhillipsJr.


Proteins from psychrophilic organisms can function at low temperatures and have shown potential for industrial applications. In the present study, thermal denaturation of a psychrophilic adenylate kinase (AKpsychro) from Bacillus globisporus was measured using circular dichroism spectroscopy and its molecular dynamics (MD) simulations were performed. The results from the unfolding experiment and MD simulations of AKpsychro were compared with those of its mesophilic and thermophilic homologues to study the relationship between dynamic motion and the cold adaptation of proteins.


Adenylate kinase Enzyme Molecular dynamics simulation Protein Psychrophile 



This work was supported by the Seoul National University Research Grant and the Cooperative Research Programme for Agricultural Science & Technology Development funded by Rural Development Administration (PJ009781).


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Copyright information

© The Korean Society for Applied Biological Chemistry 2015

Authors and Affiliations

  • Euiyoung Bae
    • 1
    • 4
    • 2
  • Sojin Moon
    • 1
  • George N. PhillipsJr.
    • 2
    • 3
  1. 1.Department of Agricultural BiotechnologySeoul National UniversitySeoulRepublic of Korea
  2. 2.Department of BiochemistryUniversity of Wisconsin-MadisonMadisonUSA
  3. 3.Department of Biochemistry and Cell BiologyRice UniversityHoustonUSA
  4. 4.Center for Food and Bioconvergence, and Research Institute of Agriculture and Life SciencesSeoul National UniversitySeoulRepublic of Korea

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