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Isolation and identification of α-glucosidase inhibitors from the stem bark of the nutgall tree (Rhus javanica Linné)

  • Jeong-Yong Cho
  • Kang-Deok Lee
  • Sun-Young Park
  • Won Chul Jeong
  • Jae-Hak Moon
  • Kyung-Sik HamEmail author
Original Article Bioactive Materials

Abstract

Ethyl acetate (EtOAc) layer obtained after the solvent fractionation of hot water extracts from nutgall tree (Rhus javanica) stem bark showed higher α-glucosidase inhibition activity than other layers. A novel acetophenone glucoside (4) and six known phenolic compounds were isolated from the EtOAc layer. The structure of 4 was determined to be 3,4,5-trihydroxyacetophenone 4-O-β-d-glucopyranoside. The six known compounds were identified as gallic acid (1), 5-methylresorcinol (2), methylgallate (3), 3-hydroxy-5-methylphenol 1-O-β-d-(6′-galloyl)glucopyranoside (5), scopoletin (6), and phlorizin (7). Their chemical structures were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance analyses. Compound 5 was newly identified from this plant. Compounds 6 and 7 showed significantly higher α-glucosidase inhibition activity than other compounds.

Keywords

acetophenone glucoside galloylglucoside α-glucosidase inhibitor nutgall tree phenolics Rhus javanica 

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Copyright information

© The Korean Society for Applied Biological Chemistry 2013

Authors and Affiliations

  • Jeong-Yong Cho
    • 1
  • Kang-Deok Lee
    • 1
  • Sun-Young Park
    • 1
  • Won Chul Jeong
    • 1
  • Jae-Hak Moon
    • 2
  • Kyung-Sik Ham
    • 1
    Email author
  1. 1.Department of Food Science & Biotechnology and Solar Salt Biotechnology Research CenterMokpo National UniversityMuan, JeonnamRepublic of Korea
  2. 2.Department of Food Science & Technology, and Functional Food Research CenterChonnam National UniversityGwangjuRepublic of Korea

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