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Fate, occurrence, and toxicity of veterinary antibiotics in environment

  • Ramasamy Rajesh Kumar
  • Jae Taek Lee
  • Jae Young ChoEmail author
Review

Abstract

The increasing worldwide usages of Veterinary Antibiotics (VAs) for therapeutic and nontherapeutic are becoming serious issue due to its adverse effects on all living organisms. Release of VAs into the aquatic and terrestrial environments results in antibiotic resistance in bacteria and toxicity to humans, animals, and plants. This review covers the present scenario on VA usage, occurrence, toxicity, and removal techniques.

Keywords

antibiotics antibiotic-resistance toxicity veterinary 

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References

  1. Asai T, Harada K, Ishihara K, Kojima A, Sameshima T, Tamura Y et al. (2007) Association of antimicrobial resistance in campylobacter isolated from food-producing animals with antimicrobial use on farms. Jpn J Infect Dis 60, 2904.Google Scholar
  2. Awad YM, Lee SS, Kim SC, Yang JE, and Ok YS (2010) Novel approaches to monitoring and remediation of veterinary antibiotics in soil and water. Korean J Environ Agric 29, 315–327.CrossRefGoogle Scholar
  3. Baguer AJ, Jensen J, and Krogh PH (2000) Effects of the antibiotics oxytetracycline and tylosin on soil fauna. Chemosphere 40, 751–757.CrossRefGoogle Scholar
  4. Batchelder AR (1981) Chlortetracycline and oxytetracycline effects on plant growth and development in liquid culture. J Environ Qual 10, 515–518.CrossRefGoogle Scholar
  5. Batchelder AR (1982) Chlorotetracycline and oxytetracycline effects on plant growth and development in soil systems. J Environ Qual 11, 675–678.CrossRefGoogle Scholar
  6. Ben W, Qiang Z, Pan X, and Chen M (2009) Removal of veterinary antibiotics from sequencing batch reactor (SBR) pretreated swine wastewater by Fenton’s reagent. Water Res 43, 4392–4402.CrossRefGoogle Scholar
  7. Ben Z, Qiang PE, and Nie Y (2012) Degradation of veterinary antibiotics by ozone in swine wastewater pretreated with sequencing batch reactor. J Environ Eng 138, 272–277.CrossRefGoogle Scholar
  8. Benbrook CM (2002) Antibiotic drug use in U.S. aquaculture. Institute for Agriculture and Trade Policy, Washington, USA.Google Scholar
  9. Boreen AL, Arnold XA, and McNeill K (2004) Photochemical fate of sulfa drugs in the aquatic environment: Sulfa drugs containing five-membered heterocyclic groups. Environ Sci Technol 38, 3933–3940.CrossRefGoogle Scholar
  10. Boreen AL, Arnold WA, and McNeill K (2005) Triplet-sensitized photodegradation of sulfa drugs containing six-membered heterocyclic groups: Identification of an SO2 extrusion photoproduct. Environ Sci Technol 39, 3630–3638.CrossRefGoogle Scholar
  11. Boxall ABA, Blackwell PA, Cavallo R, Kay P, and Tolls J (2002) The sorption and transport of a sulphonamide antibiotics in soil systems. Toxicol Lette 131, 19–28.CrossRefGoogle Scholar
  12. Burhenne J, Ludwig M, Nikoloudis P, and Spiteller M (1997) Photolytic de-gradation of fluoroquinolone carboxylic acids in aqueous solution. 1. Primary photoproducts and half-lives. Environ Sci Pollut Res 4, 10–15.CrossRefGoogle Scholar
  13. Calisto V and Esteves VI (2009) Psychiatric pharmaceuticals in the environment. Chemosphere 77, 1257–1274.CrossRefGoogle Scholar
  14. Chung BY, Lee SG, and Cho JY (2009) Advanced oxidation process of veterinary antibiotic tetracycline by electron beam irradiation. J Korean Soc Appl Biol Chem 52, 675–680CrossRefGoogle Scholar
  15. Cunningham V (2008) Special characteristics of pharmaceuticals related to environmental fate. In Phramceuticals in the Environment. Sources, Fate, Effects and Risk (3rd ed.), Kümmerer K (ed.), pp. 23–24, Springer, Berlinn Heidelberg, Germany.Google Scholar
  16. Díaz-Cruz MS, de Alda MJL, and Barceló D (2006) Determination of antimicrobials in sludge from infiltration basins at two artificial recharge plants by pressurized liquid extraction-liquid chromatography-tandem mass spectrometry. J Chromatogr A 1130, 72–82.CrossRefGoogle Scholar
  17. Díaz-Cruz MS, López de Alda MJ, and Barceló D (2003) Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge. Trend Anal Chem 22, 340–351.CrossRefGoogle Scholar
  18. Doi AM and Stoskopf MK (2000) The kinetics of oxytetracycline degradation in deionized water under varying temperature, pH, light, substrate, and organic matter. J Aquat Anim Health 12, 246–253.CrossRefGoogle Scholar
  19. EMA (European Medicines Agency) (2011) Trends in the sales of veterinary antimicrobial agents in nine European countries (2005–2009). (EMA/238630/2011), UK.Google Scholar
  20. García-Galán MJ, Rodríguez-Rodríguez CE, Vicent T, Caminal G, Díaz-Cruz MS, and Barceló D (2011) Biodegradation of sulfamethazine by Trametes versicolor: Removal from sewage sludge and identification of intermediate products by UPLC-QqTOF-MS. Sci Total Environ 409, 5505–5512.CrossRefGoogle Scholar
  21. Göbel A, Thomsen A, McArdell CS, Alder AC, Giger W, Theib et al. (2005) Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge. J Chromatogr A 1085, 179–189.CrossRefGoogle Scholar
  22. Golet EM, Xifra I, Siegrist H, Alder AC, and Giger W (2003) Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil. Environ Sci Technol 37, 3243–3249.CrossRefGoogle Scholar
  23. Haller MY, Müller SR, McArdell CS, Alder AC, and Suter MJF (2002) Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. J Chromatog A 952, 111–120.CrossRefGoogle Scholar
  24. Halling-Sørenson B, Sengelov G, and Tjornelund J (2002) Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria, including selected tetracycline resistant bacteria. Arch Environ Contam Toxicol 42, 236–271.CrossRefGoogle Scholar
  25. Halling-Sørensen B, Sengeløv G, Ingerslev F, and Jensen LB (2003) Reduced antimicrobial potencies of oxytetracycline, tylosin, sulfadiazin, streptomycin, ciprofloxacin, and olaquindox due to environmental processes. Arch Environ Contam Toxicol 44, 7–16.CrossRefGoogle Scholar
  26. Hamscher G, Sczesny S, Höper H, and Nau H (2002) Determination of persistent tetracycline residues in soil fertilised with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Anal Chem 74, 1509–1518.CrossRefGoogle Scholar
  27. Hertenberger G, Zampach P, and Bachmann G (2002) Plant species affect the concentration of free sugars and free amino acids in different types of soil. J Plant Nut Soil Sci 165, 557–565.CrossRefGoogle Scholar
  28. Hiltner L (1904) Uber neuere erfarungen und probleme auf dem gebiet der bodenbakteriologie und unter besonderer berucksichtigung der grundung und brache. Arbeiten der Deutsche Landwirtschafts-Gesellschaft 98, 59–78.Google Scholar
  29. Hoa PTP, Managaki S, Nakada N, Takada H, Shimizu A, Anh DH et al. (2011) Antibiotic contamination and occurrence of antibiotic-resistant bacteria in aquatic environments of northern Vietnam. Sci Total Environ 409, 2894–2901.CrossRefGoogle Scholar
  30. Holzel CS, Schwaiger K, Harms K, Kuchenhoff H, Kunz A, Meyer K et al. (2010) Sewage sludge and liquid pig manure as possible sources of antibiotic resistant bacteria. Environ Res 110, 318–326.CrossRefGoogle Scholar
  31. Hu XG, Luo Y, Zhou QX, and Xu L (2008) Determination of thirteen antibiotics residues in manure by solid phase extraction and high performance liquid chromatography. Chin J Anal Chem 36, 1162–1166.CrossRefGoogle Scholar
  32. Ikehata K, Naghashkar NJ, and EI-Din MG (2006) Degradation of aqueous pharmaceuticals by ozonation and advanced oxidation processes: A review. Ozone Sci Eng 28, 353–414.CrossRefGoogle Scholar
  33. Jacobsen AM and Halling-Sørensen B (2006) Multi-component analysis of tetracyclines, sulfonamides and tylosin in swine manure by liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 384, 1164–1174.CrossRefGoogle Scholar
  34. JETACAR (Joint Expert Advisory Committee on Antibiotic Resistance) (1999) The use of antibiotics in food-producing animals: antibiotic resistance bacteria in animals and humans. Commonwealth Department of health and aged care. Common wealth Department of Agriculture, Fisheries and Forestry, Australia. ISBN 1 86496 0612.Google Scholar
  35. Jian-hua Y, De-kui N, Zhao-jun L, Yong-chao L, and Shu-qing Z (2010) Effects of antibiotics oxytetracycline on soil enzyme activities and microbial biomass in wheat rhizosphere. Scientia Agricultura Sinica 43, 721–728 (in Chinese)Google Scholar
  36. Jjemba PK (2002a) The effect of chloroquine, quinacrine, and metronidazole on both soybean plants and soil microbiota. Chemosphere 46, 1019–1025.CrossRefGoogle Scholar
  37. Jjemba PK (2002b) The potential impact of veterinary and human therapeutic agents in manure and biosolids on plants grown on arable land: a review. Agric Ecosyst Environ 93, 267–278.CrossRefGoogle Scholar
  38. Jørgensen SE and Halling-Sørensen B (2000) Drugs in the environment. Chemosphere 40, 691–699.CrossRefGoogle Scholar
  39. Kallenborn R, Fick J, Lindberg R, Moe M, Nielsen KM, Tysklind M et al. (2008) Pharmaceutical residues in Northern European environments: consequences and perspectives. In Pharmaceuticals in the Environment. Sources, Fate, Effects and Risk (3rd ed.), Kümmerer K (ed.), pp. 61–74, Springer, Berlin Heidelberg, Germany.Google Scholar
  40. Karcı A and Balcıoğlu IA (2009) Investigation of the tetracycline, sulfonamide, and fluoroquinolone antimicrobial compounds in animal manure and agricultural soils in Turkey. Sci Total Environ 407, 4652–4664.CrossRefGoogle Scholar
  41. Kemper N (2008) Veterinary antibiotics in the aquatic and terrestrial environment. Ecol Indic 8, 1–13.CrossRefGoogle Scholar
  42. Kim KR, Owens G, Kwon SI, So KH, Lee DB, Ok YS (2011) Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment. Water Air Soil Poll 214, 1–4.CrossRefGoogle Scholar
  43. Kümmerer K (2009) Antibiotics in the aquatic environment. Chemosphere 75, 417–434.CrossRefGoogle Scholar
  44. Kümmerer K and Henninger A (2003) Promoting resistance by the emission of antibiotics from hospitals and households into effluents. Clin Microbiol Infec 9, 1203–1214.CrossRefGoogle Scholar
  45. Larcher S and Yargeau V (2011) Biodegradation of sulfamethoxazole by individual and mixed bacteria. Appl Microbiol Biotechnol 91, 211–218.CrossRefGoogle Scholar
  46. Liu F, Ying GG, Tao R, Zhao JL, Yang JF, and Zhao LF (2009) Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environ Pollut 157, 1636–1642.CrossRefGoogle Scholar
  47. Liu XC, Dong YH, and Wang H (2007) Residual tetracyclines in manure from concentrated animal feeding operations in Jiangsu Province. J Agro-Environ Sci 27, 1177–1182 (in Chinese).Google Scholar
  48. Loftin KA, Adams CD, Meyer MT, and Surampalli R (2008) Effects of ionic strength, temperature, and pH on degradation of selected antibiotics. J Environ Qual 37, 378–386.CrossRefGoogle Scholar
  49. Lunestad BT, Tore B, Samuelsen OB, Fjelde S, and Ervik A (1995) Photostability of eight antibacterial agents in seawater. Aquaculture 134, 217–225.CrossRefGoogle Scholar
  50. Mark C, Christian F, Enric M, Paul MM, and Ian P (2003) The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. J Anti Chemo 52, 159–161CrossRefGoogle Scholar
  51. Martínez-Carballo E, González-Barreiro C, Scharf S, and Gans O (2007) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environ Pollut 148, 570–579.CrossRefGoogle Scholar
  52. Martinez JL (2009) Environmental pollution by antibiotics and by antibiotic resistance determinants. Environ Pollut 157, 2893–2902.CrossRefGoogle Scholar
  53. Migliore L, Brambilla G, Cozzolino S, and Gaudio L (1995) Effects on plants of sulphadimethoxine used in intensive farming (Panicum milieceum, Pisum sativum and Zea mays). Agric Ecosyst Environ 52, 103–110.CrossRefGoogle Scholar
  54. Migliore L, Civitareale C, Brambilla G, Cozzolino S, Casoria P, and Gaudio L (1997) Effect of sulphadimethoxine on cosmopolitan weeds (Amaranthus retroflexus L., Plantago major L., and Rumex acetosella L.). Agric Ecosyst Environ 65, 163–168.CrossRefGoogle Scholar
  55. Migliore L, Civitareale C, Cozzolino S, Casoria P, Brambilla G, and Gaudio L (1998) Laboratory models to evaluate phytotoxicity of sulphadimethoxine on terrestrial plants. Chemosphere 37, 2957–2961.CrossRefGoogle Scholar
  56. Migliore L, Cozzolino S, and Fiori M (2003) Phytotoxicity to and uptake of enrofloxacin in crop plants. Chemosphere 52, 1233–1244.CrossRefGoogle Scholar
  57. Miller GC and Donaldson SG (1994) Factors affecting photolysis of organic compounds on soils. In Aquatic and Surface Photochemistry (6). Helz GR, Zepp RG, and Currier RW (eds.), pp. 97–109, Lewis Publishers, Boca Raton, USA.Google Scholar
  58. Mitema ES, Kikuvi GM, Wegener HC, and Stohr K (2001) An assessment of antimicrobial consumption in food producing animals in Kenya. J Vet Pharmacol Therap 24, 385–390.CrossRefGoogle Scholar
  59. NAAS (National Academy of Agricultural sciences) (2010) Antibiotics in manure and soil-A grave threat to human and animal health. Policy paper no 43, pp. 20, New Delhi, India.Google Scholar
  60. Ok YS, Kim SC, Kim KR, Lee SS, Moon DH, Lim KJ et al. (2011) Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province, Korea. Environ Monit Assess 174, 1–4.CrossRefGoogle Scholar
  61. Oka H, Ikai Y, Kawamura N, Yamada M, Harada K, Ito M et al. (1989) Photodecomposition products of tetracyclines in aqueous solution. J Agric Food Chem 37, 226–231.CrossRefGoogle Scholar
  62. Pan X, Qiang Z, Ben W, and Chen C (2011) Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China. Chemosphere 84, 695–700.CrossRefGoogle Scholar
  63. Pouliquen H, Delepee R, Larhantec-Verdier M, Morvan M-L, and Bris HL (2007) Comparative hydrolysis and photolysis of four antibacterial agents (oxytetracycline, oxolinic acid, flumequine and florfenicol) in deionised water, freshwater and seawater under abiotic conditions. Aquaculture 262, 23–28.CrossRefGoogle Scholar
  64. Prado N, Ochoa J, and Amrane A (2009) Biodegradation and biosorption of tetracycline and tylosin antibiotics inactivated sludge system. Proc Biochem 44, 1302–1306.CrossRefGoogle Scholar
  65. Qingxiang Y, Jing Z, Kongfang K, and Hao Z (2009) Influence of oxytetracycline on the structure and activity of microbial community in wheat rhizosphere soil. J Environ Sci 21, 954–959.CrossRefGoogle Scholar
  66. Renee J (2011) Potential trade implications of restrictions on antimicrobial use in animal production. p. 118. Congressional Research Service (CRS) Report for congress prepared for members and committees of congress. Congressional Research Service, USA.Google Scholar
  67. Rodarte-Morales AI, Moreira MT, Feijoo G, and Lema JM (2011) Degradation of selected pharmaceutical and personal care products (PPCPs) by white-rot fungi. World J Microbiol Biotechnol 27, 1839–1846.CrossRefGoogle Scholar
  68. Sarmah AK, Meyer MT, and Boxall ABA (2006) A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65, 725–759.CrossRefGoogle Scholar
  69. Seo YH, Choi JK, Kim SK, Min HK, and Jung YS (2007) Prioritizing environmental risks of veterinary antibiotics based on the use and the potential to reach environment. Korean J Soil Sci Fertil 40, 43–50.Google Scholar
  70. Shi YJ, Wang XH, Qi Z, Diao MH, Gao MM, Xing SF et al. (2011) Sorption and biodegradation of tetracycline by nitrifying granules and the toxicity of tetracycline on granules. J Hazard Mater 191, 103–109.CrossRefGoogle Scholar
  71. Sim WJ, Lee JW, Lee ES, Shin SK, Hwang SR, and Oh JE (2011) Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures. Chemosphere 82, 179–186.CrossRefGoogle Scholar
  72. Tao R, Ying GG, Su HC, Zhou HW, and Sidhu JPS (2010) Detection of antibiotic resistance and tetracycline resistance genes in Enterobacteriaceae isolated from the Pearl rivers in South China. Environ Pollut 158, 2101–2109.CrossRefGoogle Scholar
  73. Thiele-Bruhn S (2003) Pharmaceutical antibiotic compounds in soils. J Plant Nutr Soil Sci 166, 145–167.CrossRefGoogle Scholar
  74. Thiele-Bruhn S and Peters D (2007) Photodegradation of pharmaceutical antibiotics on slurry and soil surfaces. Landbauforschung Völkenrode 57, 13–23.Google Scholar
  75. Watts CD, Crathorne B, Fielding M, and Killops SD (1982) Nonvolatile organic compounds in treated waters. Environ Health Persp 46, 87–89.CrossRefGoogle Scholar
  76. Wei RC, Wang R, Li W, Chen M, and Zheng Q (2008) Determination method of chlortetracycline residues in pig faeces. Acta Agricult Zhejiang 20, 291–295 (in Chinese).Google Scholar
  77. Werner JJ, Arnold WA, and McNeill K (2006) Water hardness as a photochemical parameter: tetracycline photolysis as a function of calcium concentration, magnesium concentration, and pH. Environ Sci Technol 40, 7236–7241.CrossRefGoogle Scholar
  78. Wise R (2002) Antimicrobial resistance: priorities for action. J Antimicrob Chemotherp 49, 585–586.CrossRefGoogle Scholar
  79. Wolters A and Steffens N (2005) Photodegradation of antibiotics on soil surfaces: Laboratory studies on sulfadiazine in an ozone-controlled environment. Environ Sci Technol 39, 6071–6078.CrossRefGoogle Scholar
  80. Xuan R, Arisi L, Qiquan W, Scott RY, and Biswas K (2010) Hydrolysis and photolysis of oxytetracycline in aqueous solution. J Environ Sci Health Part B 45, 73–81.CrossRefGoogle Scholar
  81. Yang CH and Crowley DE (2000) Rhizosphere microbial community structure in relation to root location and plant iron nutritional status. Appl Environ Microbiol 66, 345–351.CrossRefGoogle Scholar
  82. Yang SF, Lin CF, Lin AY, and Hong PK (2011) Sorption and biodegradation of sulfonamide antibiotics by activated sludge: Experimental assessment using batch data obtained under aerobic conditions. Water Res 45, 3389–3397.CrossRefGoogle Scholar
  83. Zhang HM, Zhang MK, and Gu GP (2008) Residues of tetracyclines in livestock and poultry manures and agricultural soils from north Zhejiang province. J Ecol Rural Environ 24, 69–73 (in Chinese).Google Scholar
  84. Zhang SQ, Zhang FD, Liu XM, Wang YJ, Zou SW, and He XS (2005) Determination and analysis on main harmful composition in excrement of scale livestock and poultry feedlots. Plant Nutr Fert Sci 11, 822–829 (in Chinese).Google Scholar
  85. Zhao L, Dong YH, and Wang H (2010) Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China. Sci Tot Environ 408, 1069–1075.CrossRefGoogle Scholar

Copyright information

© The Korean Society for Applied Biological Chemistry 2012

Authors and Affiliations

  • Ramasamy Rajesh Kumar
    • 1
  • Jae Taek Lee
    • 1
  • Jae Young Cho
    • 1
    Email author
  1. 1.Bio-environmental ChemistryChonbuk National UniversityJeonjuRepublic of Korea

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