Advertisement

Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

  • Gyu-Won Huh
  • Dae-Young Lee
  • Suh-Ji In
  • Don-Gil Lee
  • Sang Yong Park
  • Tae-Hoo Yi
  • Hee Cheol Kang
  • Woo-Duck Seo
  • Nam-In BaekEmail author
Short Communication

Abstract

Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

Keywords

24,28-epoxy-24-ethylcholesterol fucosterol Hizikia fusiformis osteosarcoma 24R-saringosterol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bang MH, Kim HH, Lee DY, Han MW, Baek YS, Chung DK et al. (2011) Anti-osteoporotic activities of fucosterol from sea mustard (Undaria pinnatifida). Food Sci Biotechnol 20, 343–347.CrossRefGoogle Scholar
  2. Billiau A, Cassiman JJ, Willems D, Verhelst M, and Heremans H (1975) In vitro cultivation of human tumor tissues. Oncology 31, 257–272.CrossRefGoogle Scholar
  3. Bollen AM, Taguchi A, Hujoel PP, and Hollender LG (2000) Casecontrol study on self reported osteoporotic fractures and mandibular cortical bone. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90, 518–524.CrossRefGoogle Scholar
  4. Borrell LN and Papapanou PN (2005) Analytical epidemiology of periodontitis. J Clin Periodontol 32(Suppl 6), 132–158.CrossRefGoogle Scholar
  5. Hwang HJ, Kim IH, and Nam TJ (2008) Effect of a glycoprotein from Hizikia fusiformis on acetaminophen-induced liver injury. Food Chem Toxicol 46, 3475–3481.CrossRefGoogle Scholar
  6. Kim KI, Seo HD, Lee HS, Cho HY, and Yang HC (1998) Studies on the blood anticoagulant polysaccharide isolated from hot water extracts of Hizikia fusiforme. J Korean Soc Food Sci Nutr 27, 1204–1210.Google Scholar
  7. Labelle D, Jumarie C, and Moreau R (2007) Capacitative calcium entry and proliferation of human osteoblast-like MG-63 cells. Cell Prolif 40, 866–884.CrossRefGoogle Scholar
  8. Lee JM, Kang BH, and Kim YK (2010) Drying condition affects total phenol contents and antioxidant activities of Hizikia fusiformis. J Food Sci Nutr 15, 244–247.CrossRefGoogle Scholar
  9. Lee SH, Lee YS, Jung SH, Kang SS, and Shin KH (2003) Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa. Arch Pharm Res 26, 719–722.CrossRefGoogle Scholar
  10. Martínez-Maestre MÁ, González-Cejudo C, Machuca G, Torrejón R, and Castelo-Branco C (2010) Periodontitis and osteoporosis: a systematic review. Climacteric 13, 523–529.CrossRefGoogle Scholar
  11. Nagai T and Yukimoto T (2003) Preparation and functional properties of beverages made from sea algae. Food Chem 80, 29–33.CrossRefGoogle Scholar
  12. Pejèiæ A, Kojoviæ D, Grigorov I, and Stamenkoviæ B (2005) Periodontitis and osteoporosis. Facta Univ Ser Med Biol 12, 100–103.Google Scholar
  13. Saag KG and Geusens P (2009) Progress in osteoporosis and fracture prevention: focus on postmenopausal women. Arthritis Res Ther 11, 251.CrossRefGoogle Scholar
  14. Siriwardhana N, Lee KW, Kim SH, Ha JH, Park GT, and Jeon YJ (2004) Lipid peroxidation inhibitory effects of Hizikia fusiformis methanolic extract on fish oil and linoleic acid. Food Sci Technol Int 10, 65–72.CrossRefGoogle Scholar
  15. Taguchi A, Tanimoto K, Suei Y, and Wada T (1995) Tooth loss and mandibular osteopenia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79, 127–132.CrossRefGoogle Scholar
  16. Verhoef CM, Roon JAG, Vianen ME, Lafeber FPJG, and Bijlsma JWJ (1999) The immune suppressive effect of dexamethasone in rheumatoid arthritis is accompanied by upregulation of interleukin 10 and by differential changes in interferon ã and interleukin 4 production. Ann Rheum Dis 58, 49–54.CrossRefGoogle Scholar
  17. Wang W, Li HY, Wang YY, Xia X, Okada Y, and Okuyama T (2008) Chemical constituents from brown alga Sargassum fusiforme. Chin Trad Herb Drugs 39, 657–661.Google Scholar
  18. Yan X, Chuda Y, Suzuki M, and Nagata T (1999) Fucoxanthin as the major antioxidant in Hizikia fusiformis, a common edible seaweed. Biosci Biotech Biochem 63, 605–607.CrossRefGoogle Scholar
  19. Yaoita Y, Amemiya K, Ohnuma H, Furumura K, Masaki A, Matsuki T et al. (1998) Sterol constituents from five edible mushrooms. Chem Pharm Bull 46, 944–950.CrossRefGoogle Scholar
  20. Yaoita Y, Matsuki K, Iijima T, Nakano S, Kakuda R, Machida K et al. (2001) New sterols and triterpenoids from four edible mushrooms. Chem Pharm Bull 49, 589–594.CrossRefGoogle Scholar

Copyright information

© The Korean Society for Applied Biological Chemistry 2012

Authors and Affiliations

  • Gyu-Won Huh
    • 1
  • Dae-Young Lee
    • 1
  • Suh-Ji In
    • 1
  • Don-Gil Lee
    • 1
  • Sang Yong Park
    • 1
  • Tae-Hoo Yi
    • 1
  • Hee Cheol Kang
    • 2
  • Woo-Duck Seo
    • 3
  • Nam-In Baek
    • 1
    Email author
  1. 1.The Graduate School of Biotechnology and Department of Oriental Medicinal Materials & ProcessingKyung Hee UniversityYonginRepublic of Korea
  2. 2.GFC Co., Ltd.SuwonRepublic of Korea
  3. 3.Department of Functional CropNational Institute of Crop Science, RDAMilyangRepublic of Korea

Personalised recommendations