Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from wheat bran

  • Seong Su Hong
  • Joa Sub OhEmail author
Original Article Bioactive Materials


Chromatographic separation of ethanol extract of wheat bran led to the isolation of five 5-alk(en)ylresorcinols, four aliphatic compounds, and one phenolic glycoside. These were, respectively: 5-n-heptadecylresorcinol (1), 5-n-14′-(Z)-heneicosylresorcinol (2), 5-n-nonadecylresorcinol (3), 5-n-heneicosylresorcinol (4), 5-n-tricosylresorcinol (5), 1-O-(9Z,12Z,15Z-octadecatrienoate) glycerol (6), 2-linoleoylglycerol (7), 1-O-(9Z,12Z-octadecatrienoate)glycerol (8), pinellic acid (9), and tachioside (10). Their structures were determined by 1D- & 2D-NMR and mass spectroscopy data analysis. The inhibitory effects of isolated constituents on the release of β-hexosaminidase from RBL-2H3 cells were examined. Inhibition was shown by 5-n-nonadecylresorcinol (3), 5-n-heneicosylresorcinol (4), pinellic acid (9), and tachioside (10).


5-alk(en)ylresorcinol β-hexosaminidase RBL-2H3 cells wheat bran 


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Copyright information

© The Korean Society for Applied Biological Chemistry 2012

Authors and Affiliations

  1. 1.Natural Products Research InstituteGyeonggi Institute of Science & Technology PromotionSuwonRepublic of Korea
  2. 2.College of PharmacyDankook UniversityCheonanRepublic of Korea

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