Acta Neurologica Belgica

, Volume 119, Issue 4, pp 657–658 | Cite as

Inter-occipital communication through the anterior commissure in callosal agenesis: a necessary prerequisite for normal binocularity?

  • Tessa de Vin
  • Marcel Ten TusscherEmail author
Letter to the Editor


Morning Glory Disc Anomaly (MGDA), named after the morning glory flowers, is an optic disc anomaly characterized by an enlarged, funnel-shaped optic disc excavation, an annulus of chorioretinal pigmentary changes surrounding the excavation and a central glial tuft overlying the optic disc. Narrow, straight retinal blood vessels emerge from the periphery of the abnormal disc [1]. MGDA is typically unilateral and should be distinguished from other congenital disc lesions, especially optic nerve coloboma (ONC) and peripapillary staphyloma [2].

In MGDA there is an important association with midline facial anomalies including hypertelorism, cleft lip and cleft palate, as well as with midline central nervous system anomalies such as basal encephalocele, pituitary gland abnormalities and agenesis of the corpus callosum [3].

Cerebral midline pathology is strongly associated with strabismus [4]. Partial decussation at the optic chiasm in binocular mammals with front facing eyes...



The authors did not receive funding for this study.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to disclose.

Ethical standards

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and later amendments.

Informed consent

Informed consent was obtained.


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    Lee BJ, El Traboulsi (2008) Update on the morning glory disc anomaly. Ophthalmic Genet 29(2):47–52CrossRefGoogle Scholar
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    Van Meer N, Houtman Anne C, Van Schuerbeek P, Vanderhasselt T, Milleret C, ten Tusscher MPM (2016) Interhemispheric connections between the primary visual cortical areas via the anterior commissure in human callosal agenesis. Front Syst Neurosci. 10:101PubMedPubMedCentralGoogle Scholar

Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyUniversity Hospital, Vrije Universiteit BrusselBrusselsBelgium

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