Isolated central acute vestibular syndrome following nucleus prepositus hypoglossi infarction

  • Chenguang Zhou
  • Yi SuiEmail author
  • Yuanhong HeEmail author
  • Zhiqiang Xu
  • Yaoyao Shen
Letter to the Editor

Dear Editor,

Isolated vertigo following lesions to the nucleus prepositus hypoglossi is extremely rare. Herein, we report a patient who presented with isolated central acute vestibular syndrome. Magnetic resonance imaging (MRI) revealed acute infarction involving the isolated nucleus prepositus hypoglossi in the dorsal medial medulla oblongata and pons. The case illustrates that isolated acute vestibular syndrome can be caused by a rare nucleus prepositus hypoglossi infarction.

A 60-year-old woman who presented with sudden-onset vertigo and unsteadiness was referred to our neurological ward. She had a medical history of hypercholesterolemia, Type 2 diabetes mellitus, ischemic stroke and coronary artery disease. On admission, her blood pressure was 200/96 mmHg and heart rate was 86 beats/min. She was in agony with closed eyes and presented with frequent nausea and vomiting in response to slight head movements. The neurological examination disclosed prominent, spontaneous, left beating...


Nucleus prepositus hypoglossi Vertigo Acute vestibular syndrome 



The authors thank the staff of neurological 1, Peng Wang, Shanshan Liu, Du Cheng, Xiaorui Tian and Kui Li for case discussion, Longnv Luo for her assistance in preparation of the manuscript.


This work was supported by Key Research Program for Higher Education of Henan Province, China, (ID 18A320071)

Compliance with ethical standards

Conflict of interest

We declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. In addition, the consent was obtained from the patient for the publication of this case report.


  1. 1.
    Kerber KA, Brown DL, Lisabeth LD et al (2006) Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke 37(10):2484–2487CrossRefGoogle Scholar
  2. 2.
    Seo SW, Shin HY, Kim SH et al (2004) Vestibular imbalance associated with a lesion in the nucleus prepositus hypoglossi area. Arch Neurol 61(9):1440–1443CrossRefGoogle Scholar
  3. 3.
    Cho HJ, Choi HY, Kim YD et al (2008) The clinical syndrome and etiological mechanism of infarction involving the nucleus prepositus hypoglossi. Cerebrovasc Dis 26(2):178–183CrossRefGoogle Scholar
  4. 4.
    Arts MP, De Zeeuw CI, Lips J, Rosbak E, Simpson JI (2000) Effects of nucleus prepositus hypoglossi lesions on visual climbing fiber activity in the rabbit flocculus. J Neurophysiol 84:2552–2563CrossRefGoogle Scholar
  5. 5.
    Tatu L, Moulin T, Bogousslavsky J, Duvernoy H (1996) Arterial territories of human brain: brainstem and cerebellum. Neurology. 47:1125–1135CrossRefGoogle Scholar

Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  1. 1.Department of NeurologyThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  2. 2.Department of Neurology, Shenyang First People’s Hospital, Shenyang Brain InstituteShenyang Medical College Affiliated Shenyang Brain HospitalShenyangChina
  3. 3.Department of NeurologyZheng Zhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouChina
  4. 4.The Affiliated Hospital of Jiujiang UniversityJiujiangChina

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