Injury of the prefronto-caudate tract in a patient with apathy following intracerebral hemorrhage in the caudate nucleus
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The caudate nucleus (CN), as a part of the basal ganglia, interconnects with the prefrontal cortex (PFC), temporal cortex, frontal eye field, and cerebellum. These connections are involved in motor and cognitive functions . Specifically, the prefronto-caudate tract is involved in apathy, anxiety, depression, and disinhibition . Apathy is classically defined as a lack of feeling, emotion, interest and concern, and clinically presents as the absence of motivation, voluntary movement or speech . Injury of the CN, PFC, or the prefronto-caudate tract in particular, connected to the medial PFC, and orbitofrontal cortex (OFC) is related to apathy [4, 5].
Diffusion tensor tractography (DTT), a three-dimensional imaging tool, is based on diffusion tensor imaging (DTI). This technique measures characteristics of water diffusion in brain tissue, allowing assessment of the state of neural connectivity . Probabilistic DTT, that reflects the distribution of underlying fiber...
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2018R1A2B6000996).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
The authors declare that they acted in accordance with ethical standards laid down in the 1964 Declaration of Helsinki.
Informed consent was obtained from all individual participants included in the study.
- 7.Rose SE, Chalk JB, Janke AL, Strudwick MW, Windus LC, Hannah DE, McGrath JJ, Pantelis C, Wood SJ, Mowry BJ (2006) Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI study. Neuroimage 32(1):16–22. https://doi.org/10.1016/j.neuroimage.2006.03.003 CrossRefGoogle Scholar
- 8.Casey BJ, Epstein JN, Buhle J, Liston C, Davidson MC, Tonev ST, Spicer J, Niogi S, Millner AJ, Reiss A, Garrett A, Hinshaw SP, Greenhill LL, Shafritz KM, Vitolo A, Kotler LA, Jarrett MA, Glover G (2007) Frontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHD. Am J Psychiatry 164(11):1729–1736. https://doi.org/10.1176/appi.ajp.2007.06101754 CrossRefGoogle Scholar
- 9.Schweren LJ, Hartman CA, Zwiers MP, Heslenfeld DJ, Franke B, Oosterlaan J, Buitelaar JK, Hoekstra PJ (2016) Stimulant treatment history predicts frontal-striatal structural connectivity in adolescents with attention-deficit/hyperactivity disorder. Eur Neuropsychopharmacol 26(4):674–683. https://doi.org/10.1016/j.euroneuro.2016.02.007 CrossRefGoogle Scholar
- 10.Myung W, Han CE, Fava M, Mischoulon D, Papakostas GI, Heo JY, Kim KW, Kim ST, Kim DJ, Kim DK, Seo SW, Seong JK, Jeon HJ (2016) Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder. Transl Psychiatry 6(6):e835. https://doi.org/10.1038/tp.2016.110 CrossRefGoogle Scholar
- 11.Trillet M, Croisile B, Tourniaire D, Schott B (1990) Disorders of voluntary motor activity and lesions of caudate nuclei. Rev Neurol (Paris) 146(5):338–344Google Scholar
- 14.Fukuoka T, Osawa A, Ohe Y, Deguchi I, Maeshima S, Tanahashi N (2012) Bilateral caudate nucleus infarction associated with a missing A1 segment. J Stroke Cerebrovasc Dis 21(8):908 e911–902. https://doi.org/10.1016/j.jstrokecerebrovasdis.2011.09.022 Google Scholar