Pyridoxine-induced sensory ataxic ganglionopathy: a case report and literature review

  • Elia Malek
  • Hassan Doumiati
  • Johnny S. SalamehEmail author
Letter to the Editor

Vitamin-B6, a water soluble vitamin, cannot be synthesized by mammals. They consume its inactive form as pyridoxine, pyridoxal and pyridoxamine. These are converted to pyridoxal phosphate (active ingredient) [1]. Pyridoxine is unsaturable and can be absorbed excessively [2]. Vitamin B6 is involved in the synthesis of neurotransmitters, thus affecting neuronal function [1].

We report a case of 54-year-old, right-handed man presented for insidious, progressive numbness and imbalance for 12 years. Past medical history was pertinent for depression on escitalopram. He is a non-smoker and works as energy consultant with no history of exposure to hazardous substances, no history of heavy alcohol intake or substance abuse. Family history was non-contributory.

First evaluation performed 9 years after symptom onset. Then, he underwent brain magnetic resonance imaging revealing no abnormalities. Otorhinolaryngology specialist ruled out vestibular causes. Video nystagmography did not reveal...


Vitamin B6 Pyridoxine Sensory ganglionopathy Sensory neuronopathy 



This paper did not receive any funding.

Compliance with ethical standards

Conflict of interest

Elia Malek M.D. declares that he has no conflict of interest. Hassan Doumiati, M.D. declares that he has no conflict of interest. Johnny Salameh, M.D. declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from the individual (reported case observation) included in this paper.


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Copyright information

© Belgian Neurological Society 2018

Authors and Affiliations

  • Elia Malek
    • 1
  • Hassan Doumiati
    • 1
  • Johnny S. Salameh
    • 1
    Email author
  1. 1.Department of NeurologyAmerican University of Beirut Medical CenterBeirutLebanon

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