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Active neuroborreliosis or inflammation: are the diagnostic guidelines at stake?

  • Harald De CauwerEmail author
  • Katrien Lagrou
  • Evelien Coeckelbergh
  • Ann Bogaerts
  • Jo Leenders
  • Dieter Vanneste
Original article

Abstract

Neuroborreliosis can induce a variety of neurological syndromes: e.g., cranial neuritis, plexitis, radiculitis, meningitis, cerebellitis, … We report on five cases of patients with a diagnosis of neuroborreliosis based on clinical symptoms, serologic tests and MR imaging results. However, neither of them fulfils the diagnostic criteria for definite neuroborreliosis. Are the diagnostic criteria still valid or is there a need to revise them? Is our diagnosis correct? Are these cases post-Lyme auto-immune neuronal inflammation, and not due to still active spirochetal infection? Do we need to consider immunosuppressive therapy instead of third-generation cephalosporins?

Keywords

Neuroborreliosis Differential diagnosis Myelitis Diagnostic criteria MR imaging. 

Notes

Compliance with ethical standards

Conflict of interest

All the authors report no disclosure or conflict of interest relevant to the manuscript.

Ethical approval

This manuscript does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study. Additional informed consent was obtained from all individual participants for whom identifying information is included in this article.

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Copyright information

© Belgian Neurological Society 2018

Authors and Affiliations

  1. 1.Department of NeurologyAZ St DimpnaGeelBelgium
  2. 2.Faculty of Medicine and Health SciencesUniversity of AntwerpWilrijkBelgium
  3. 3.Department of Microbiology and Immunology, Laboratory of Clinical Bacteriology and MycologyKU Leuven-University of LeuvenLeuvenBelgium
  4. 4.Clinical Laboratory, Laboratory of MicrobiologyAZ St DimpnaGeelBelgium
  5. 5.Department of NeuroradiologyAZ St DimpnaGeelBelgium
  6. 6.Department of NeuroradiologyUniversity Hospital GasthuisbergLeuvenBelgium

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