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Acta Neurologica Belgica

, Volume 119, Issue 1, pp 37–45 | Cite as

Eye movement abnormalities in middle cerebellar peduncle strokes

  • Sung-Hee Kim
  • Ji-Soo KimEmail author
Original Article

Abstract

The middle cerebellar peduncle (MCP) is a major conduit for cortico-ponto-cerebellar fibers that convey information related to eye movements. This study aims to elucidate eye movement abnormalities that arise from lesions confined to the MCP. In 23 patients with acute strokes restricted to unilateral MCPs, we investigated the clinical features and ocular motor findings including spontaneous nystagmus, saccades, smooth pursuit, ocular tilt reaction, and head impulse tests. Bithermal caloric tests and audiometry were also performed. Patients with strokes restricted to the MCP usually developed acute vertigo or imbalance, along with few sensorimotor signs or auditory symptoms. Patients frequently showed abnormal eye movements that included spontaneous horizontal/torsional nystagmus, ocular tilt reaction, gaze-evoked nystagmus, abnormal head impulse responses, and bilaterally impaired horizontal smooth pursuit. Unilateral MCP strokes produce acute vertigo and imbalance with distinct ocular motor abnormalities, which are primarily caused by damage to the central vestibular structures and by disruption of the neural pathways responsible for eye-position stabilization and smooth pursuit.

Keywords

Vertigo Nystagmus Stroke Middle cerebral peduncle Smooth pursuit 

Notes

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

All experiments followed the tenets of the Declaration of Helsinki. This study was approved by the Institutional Review Board of Seoul National University Bundang Hospital (IRB No. B-0910/086-102).

Informed consent

Written informed consents were obtained from the participants.

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Copyright information

© Belgian Neurological Society 2017

Authors and Affiliations

  1. 1.Department of NeurologyKyungpook National University Chilgok HospitalDaeguKorea
  2. 2.Department of NeurologySeoul National University College of Medicine, Seoul National University Bundang HospitalSeongnamKorea

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