Acta Neurologica Belgica

, Volume 118, Issue 1, pp 113–114 | Cite as

MRI findings in a case of Lissauer form of neurosyphilis

  • Elise Faraut
  • David Wallon
  • Elisabeth Gueit
  • Claire Chapuzet
  • Romain LefaucheurEmail author

A 44-year-old man was referred for aphasia, focal seizures, left upper limb paresthesia and progressive cognitive decline. These symptoms were fluctuating and had been present for at least 1 year. The patient had no prior medical history. His treatment only consisted in valproic acid (1000 mg per day) that had been introduced to treat focal seizures. At admission, clinical examination revealed no motor or clear sensitive deficit despite his complaint of left upper limb paresthesia. The patient suffered from word-finding difficulties, but speech comprehension was preserved. The patient was not a native French speaker, hence cognitive functions were difficult to evaluate. He had no psychiatric symptoms at admission. General examination was normal.

Brain MRI showed right parietal and frontal subcortical white matter hyperintensities on FLAIR images, without gadolinium enhancement on T1-weighted sequences. There was no temporal lobe atrophy. Based on the imaging findings, we hypothesized...


Leukoencephalopathy Neurosyphilis Brain MRI Lissauer 



Authors are grateful to Nikki Sabourin-Gibbs for her help in editing the manuscript.


Elise Faraut reports no financial disclosures. David Wallon reports no financial disclosures. Elisabeth Gueit reports no financial disclosures. Claire Chapuzet reports no financial disclosures. Romain lefaucheur reports no financial disclosures.

Authors contributions

Elise Faraut: acquisition of data, analysis and interpretation, critical revision of the manuscript for important intellectual content, study supervision. David Wallon: acquisition of data, analysis, and interpretation. Elisabeth Gueit: acquisition of data, analysis, and interpretation. Claire Chapuzet: acquisition of data, analysis, and interpretation. Romain Lefaucheur: acquisition of data, analysis and interpretation, critical revision of the manuscript for important intellectual content.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Patient is fully informed about case report and informed consent has been signed.


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Copyright information

© Belgian Neurological Society 2017

Authors and Affiliations

  • Elise Faraut
    • 1
  • David Wallon
    • 1
  • Elisabeth Gueit
    • 2
  • Claire Chapuzet
    • 2
  • Romain Lefaucheur
    • 1
    Email author
  1. 1.Department of NeurologyRouen University Hospital and University of RouenRouen CedexFrance
  2. 2.Department of Infectious and Tropical DiseasesRouen University Hospital and University of RouenRouen CedexFrance

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