Acta Neurologica Belgica

, Volume 117, Issue 1, pp 3–15 | Cite as

Neuroprognostication after adult cardiac arrest treated with targeted temperature management: task force for Belgian recommendations

  • Fabio Silvio Taccone
  • Ingrid Baar
  • Cathy De Deyne
  • Patrick Druwe
  • Benjamin Legros
  • Geert Meyfroidt
  • Michel Ossemann
  • Nicolas Gaspard
Consensus paper and Guideline

Abstract

The prognosis of patients who are admitted to the hospital after cardiac arrest often relies on neurological examination, which could be significantly influenced by the use of sedative drugs or the implementation of targeted temperature management. The need for early and accurate prognostication is crucial as up to 15–20% of patients could be considered as having a poor outcome and may undergo withdrawal of life-sustaining therapies while a complete neurological recovery is still possible. As current practice in Belgium is still based on a very early assessment of neurological function in these patients, the Belgian Society of Intensive Care Medicine created a multidisciplinary Task Force to provide an optimal approach for monitoring and refine prognosis of CA survivors. This Task Force underlined the importance to use a multimodal approach using several additional tools (e.g., electrophysiological tests, neuroimaging, biomarkers) and to refer cases with uncertain prognosis to specialized centers to better evaluate the extent of brain injury in these patients.

Keywords

Cardiac arrest Prognosis Hypothermia EEG Evoked potentials Biomarkers Neurological examination 

References

  1. 1.
    Callaway CW (2016) Cardiac resuscitation in 2015: improving outcomes after OHCA-targeting the layperson. Nat Rev Cardiol 13(2):70–72CrossRefPubMedGoogle Scholar
  2. 2.
    Bradley SM, Liu W, Chan PS, Nallamothu BK, Grunwald GK, Self A, Sasson C, Varosy PD, Anderson ML, Schneider PM, Ho PM, American Heart Association’s (2016) Get with the guidelines-resuscitation investigators. Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from get with the guidelines-resuscitation registry. BMJ 353:i1653CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Meaney PA, Bobrow BJ, Mancini ME, Christenson J, Caen AR, Bhanji F, Abella BS, Kleinman ME, Edelson DP, Berg RA, Aufderheide TP, Menon V, Leary M, CPR Quality Summit Investigators, The American Heart Association Emergency Cardiovascular Care Committee, The Council on Cardiopulmonary (2013) Critical care, perioperative and resuscitation. cardiopulmonary resuscitation quality: [corrected] improving cardiac resuscitation outcomes both inside and outside the hospital: a consensus statement from the American Heart Association. Circulation 128(4):417–435CrossRefPubMedGoogle Scholar
  4. 4.
    Dragancea I, Horn J, Kuiper M, Friberg H, Ullén S, Wetterslev J, Cranshaw J, Hassager C, Nielsen N, Cronberg T, TTM Trial Investigators (2015) Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: Results from a randomised controlled clinical trial. Resuscitation 93:164–170CrossRefPubMedGoogle Scholar
  5. 5.
    Lemiale V, Dumas F, Mongardon N, Giovanetti O, Charpentier J, Chiche JD, Carli P, Mira JP, Nolan J, Cariou A (2013) Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort. Intensive Care Med 39(11):1972–1980CrossRefPubMedGoogle Scholar
  6. 6.
    Sandroni C, Dell’anna AM, Tujjar O, Geri G, Cariou A, Taccone FS (2016) Acute kidney injury (AKI) after cardiac arrest: a systematic review and meta-analysis of clinical studies. Minerva Anestesiol 82(9):989–999Google Scholar
  7. 7.
    Dragancea I, Rundgren M, Englund E, Friberg H, Cronberg T (2013) The influence of induced hypothermia and delayed prognostication on the mode of death after cardiac arrest. Resuscitation 84(3):337–342CrossRefPubMedGoogle Scholar
  8. 8.
    Uchino H, Ogihara Y, Fukui H, Chijiiwa M, Sekine S, Hara N, Elmér E (2016) Brain injury following cardiac arrest: pathophysiology for neurocritical care. J Intens Care 4:31CrossRefGoogle Scholar
  9. 9.
    Nielsen N, Wetterslev J, Cronberg T, Erlinge D, Gasche Y, Hassager C, Horn J, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wise MP, Åneman A, Al-Subaie N, Boesgaard S, Bro-Jeppesen J, Brunetti I, Bugge JF, Hingston CD, Juffermans NP, Koopmans M, Køber L, Langørgen J, Lilja G, Møller JE, Rundgren M, Rylander C, Smid O, Werer C, Winkel P, Friberg H, TTM Trial Investigators (2013) Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 369(23):2197–2206CrossRefPubMedGoogle Scholar
  10. 10.
    Hypothermia after Cardiac Arrest Study Group (2002) Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346(8):549–556CrossRefGoogle Scholar
  11. 11.
    Callaway CW, Donnino MW, Fink EL, Geocadin RG, Golan E, Kern KB, Leary M, Meurer WJ, Peberdy MA, Thompson TM, Zimmerman JL (2015) Part 8: post-cardiac arrest care: 2015 American Heart Association Guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 132(18 Suppl 2):S465–S482CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Mulder M, Gibbs HG, Smith SW, Dhaliwal R, Scott NL, Sprenkle MD, Geocadin RG (2014) Awakening and withdrawal of life-sustaining treatment in cardiac arrest survivors treated with therapeutic hypothermia. Crit Care Med 42(12):2493–2499CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Sandroni C, Cariou A, Cavallaro F, Cronberg T, Friberg H, Hoedemaekers C, Horn J, Nolan JP, Rossetti AO, Soar J (2014) Prognostication in comatose survivors of cardiac arrest: an advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine. Resuscitation 85(12):1779–1789CrossRefPubMedGoogle Scholar
  14. 14.
    Taccone FS, Colpaert K, De Waele J, De Weerdt A, Hermans G, Ledoux D, Meyfroidt G, Michaux I, Sottiaux T, Wittebole X, Belgian Society of Intensive Care Medicine (2015) Targeted temperature management and neuroprognostication after cardiac arrest: a survey in Belgium. Resuscitation 96:e1–e2CrossRefPubMedGoogle Scholar
  15. 15.
    Dell’anna AM, Bini Vinotti J, Beumier M, Orbegozo-Cortes D, Donadello K, Scolletta S, Vincent JL, Taccone FS (2014) C-reactive protein levels after cardiac arrest in patients treated with therapeutic hypothermia. Resuscitation 85(7):932–938CrossRefPubMedGoogle Scholar
  16. 16.
    Samaniego EA, Mlynash M, Caulfield AF, Eyngorn I, Wijman CAC (2011) Sedation confounds outcome prediction in cardiac arrest survivors treated with hypothermia. Neurocrit Care 15(1):113–119CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Perman SM, Kirkpatrick JN, Reitsma AM, Gaieski DF, Lau B, Smith TM, Leary M, Fuchs BD, Levine JM, Abella BS, Becker LB, Merchant RM (2012) Timing of neuroprognostication in post-cardiac arrest therapeutic hypothermia. Crit Care Med 40(3):719–724CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Šunjić KM, Webb AC, Šunjić I, Palà Creus M, Folse SL (2015) Pharmacokinetic and other considerations for drug therapy during targeted temperature management. Crit Care Med 43(10):2228–2238CrossRefPubMedGoogle Scholar
  19. 19.
    Bjelland TW, Dale O, Kaisen K, Haugen BO, Lydersen S, Strand K, Klepstad P (2012) Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomised trial. Intens Care Med 38(6):959–967CrossRefGoogle Scholar
  20. 20.
    Hellström J, Öwall A, Martling CR, Sackey PV (2014) Inhaled isoflurane sedation during therapeutic hypothermia after cardiac arrest: a case series. Crit Care Med 42(2):e161–e166CrossRefPubMedGoogle Scholar
  21. 21.
    Ponz I, Lopez-de-Sa E, Armada E, Caro J, Blazquez Z, Rosillo S, Gonzalez O, Rey JR, Monedero Mdel C, Lopez-Sendon JL (2016) Influence of the temperature on the moment of awakening in patients treated with therapeutic hypothermia after cardiac arrest. Resuscitation 103:32–36CrossRefPubMedGoogle Scholar
  22. 22.
    Paul M, Bougouin W, Geri G, Dumas F, Champigneulle B, Legriel S, Charpentier J, Mira JP, Sandroni C, Cariou A (2016) Delayed awakening after cardiac arrest: prevalence and risk factors in the Parisian registry. Intensive Care Med 42(7):1128–1136CrossRefPubMedGoogle Scholar
  23. 23.
    Zandbergen EG, de Haan RJ, Reitsma JB, Hijdra A (2003) Survival and recovery of consciousness in anoxic-ischemic coma after cardiopulmonary resuscitation. Intens Care Med 29(11):1911–1915CrossRefGoogle Scholar
  24. 24.
    Irisawa T, Vadeboncoeur TF, Karamooz M, Mullins M, Chikani V, Spaite DW, Bobrow BJ (2017) Duration of coma in out-of-hospital cardiac arrest survivors treated with targeted temperature management. Ann Emerg Med 69(1):36–43CrossRefPubMedGoogle Scholar
  25. 25.
    Schefold JC, Storm C, Kruger A, Ploner CJ, Hasper D (2009) The glasgow coma score is a predictor of good outcome in cardiac arrest patients treated with therapeutic hypothermia. Resuscitation 80:658–661CrossRefPubMedGoogle Scholar
  26. 26.
    Rossetti AO, Oddo M, Logroscino G, Kaplan PW (2010) Prognostication after cardiac arrest and hypothermia: a prospective study. Ann Neurol 67(3):301–307PubMedGoogle Scholar
  27. 27.
    Sandroni C, Cavallaro F, Callaway CW, D’Arrigo S, Sanna T, Kuiper MA, Biancone M, Della Marca G, Farcomeni A, Nolan JP (2013) Predictors of poor neurological outcome in adult comatose survivors of cardiac arrest: a systematic review and meta-analysis. Part 2: Patients treated with therapeutic hypothermia. Resuscitation 84(10):1324–1338CrossRefPubMedGoogle Scholar
  28. 28.
    Freund B, Sutter R, Kaplan P (2016) Lance–Adams syndrome in the pretargeted temperature management era: a case report and systematic review. Clin EEG Neurosci. doi:10.1177/1550059416643193 PubMedGoogle Scholar
  29. 29.
    Bouwes A, van PD, Koelman JH, Kuiper MA, Zandstra DF, Weinstein HC, Tromp SC, Zandbergen EG, Tijssen MA, Horn J (2012) Acute posthypoxic myoclonus after cardiopulmonary resuscitation. BMC Neurol 12:63CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Seder DB, Sunde K, Rubertsson S, Mooney M, Stammet P, Riker RR, Kern KB, Unger B, Cronberg T, Dziodzio J, Nielsen N, International Cardiac Arrest Registry (2015) Neurologic outcomes and postresuscitation care of patients with myoclonus following cardiac arrest. Crit Care Med 43(5):965–972CrossRefPubMedGoogle Scholar
  31. 31.
    Alvarez V, Sierra-Marcos A, Oddo M, Rossetti AO (2013) Yield of intermittent versus continuous EEG in comatose survivors of cardiac arrest treated with hypothermia. Crit Care 17(5):R190CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Hofmeijer J, van Putten MJ (2016) EEG in postanoxic coma: prognostic and diagnostic value. Clin Neurophysiol 127(4):2047–2055CrossRefPubMedGoogle Scholar
  33. 33.
    Amorim E, Rittenberger JC, Baldwin ME, Callaway CW, Popescu A, Post Cardiac Arrest Service (2015) Malignant EEG patterns in cardiac arrest patients treated with targeted temperature management who survive to hospital discharge. Resuscitation 90:127–132CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Leitinger M, Beniczky S, Rohracher A, Gardella E, Kalss G, Qerama E, Höfler J, Hess Lindberg-Larsen A, Kuchukhidze G, Dobesberger J, Langthaler PB, Trinka E (2015) Salzburg Consensus Criteria for non-convulsive status epilepticus-approach to clinical application. Epilepsy Behav 49:158–163CrossRefPubMedGoogle Scholar
  35. 35.
    Gaspard N, Hirsch LJ, LaRoche SM, Hahn CD, Westover MB, EEG Critical Care, Monitoring Research Consortium (2014) Interrater agreement for Critical Care EEG Terminology. Epilepsia 55(9):1366–1373CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Rossetti AO, Logroscino G, Liaudet L, Ruffieux C, Ribordy V, Schaller MD, Despland PA, Oddo M (2007) Status epilepticus: an independent outcome predictor after cerebral anoxia. Neurology 69(3):255–260CrossRefPubMedGoogle Scholar
  37. 37.
    Rossetti AO, Oddo M, Liaudet L, Kaplan PW (2009) Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia. Neurology 72:744–749CrossRefPubMedGoogle Scholar
  38. 38.
    Cronberg T (2015) Should postanoxic status epilepticus be treated agressively? Yes! J Clin Neurophysiol 32(6):449–451CrossRefPubMedGoogle Scholar
  39. 39.
    Rossetti AO (2015) Should postanoxic status epilepticus be treated aggressively? No! J Clin Neurophysiol 32(6):447–448CrossRefPubMedGoogle Scholar
  40. 40.
    Sivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N (2015) Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intens Care Med 41(7):1264–1272CrossRefGoogle Scholar
  41. 41.
    Rundgren M, Westhall E, Cronberg T, Rosén I, Friberg H (2010) Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients. Crit Care Med 38(9):1838–1844CrossRefPubMedGoogle Scholar
  42. 42.
    Westhall E, Rossetti AO, van Rootselaar AF, Wesenberg Kjaer T, Horn J, Ullén S, Friberg H, Nielsen N, Rosén I, Åneman A, Erlinge D, Gasche Y, Hassager C, Hovdenes J, Kjaergaard J, Kuiper M, Pellis T, Stammet P, Wanscher M, Wetterslev J, Wise MP, Cronberg T, TTM-Trial Investigators (2016) Standardized EEG interpretation accurately predicts prognosis after cardiac arrest. Neurology 86(16):1482–1490CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Lamartine Monteiro M, Taccone FS, Depondt C, Lamanna I, Gaspard N, Ligot N, Mavroudakis N, Naeije G, Vincent JL, Legros B (2016) The prognostic value of 48-h continuous EEG during therapeutic hypothermia after cardiac arrest. Neurocrit Care 24(2):153–162CrossRefPubMedGoogle Scholar
  44. 44.
    Hofmeijer J, Tjepkema-Cloostermans MC, van Putten MJ (2014) Burst-suppression with identical bursts: a distinct EEG pattern with poor outcome in postanoxic coma. Clin Neurophysiol 125(5):947–954CrossRefPubMedGoogle Scholar
  45. 45.
    Rossetti AO, Urbano LA, Delodder F, Kaplan PW, Oddo M (2010) Prognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrest. Crit Care 14(5):R173CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Alvarez V, Oddo M, Rossetti AO (2013) Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) in comatose survivors of cardiac arrest: characteristics and prognostic value. Clin Neurophysiol 124(1):204–208CrossRefPubMedGoogle Scholar
  47. 47.
    Cloostermans MC, van Meulen FB, Eertman CJ, Hom HW, van Putten MJ (2012) Continuous electroencephalography monitoring for early prediction of neurological outcome in postanoxic patients after cardiac arrest: a prospective cohort study. Crit Care Med 40(10):286728–286775CrossRefGoogle Scholar
  48. 48.
    Tsetsou S, Novy J, Oddo M, Rossetti AO (2015) EEG reactivity to pain in comatose patients: Importance of the stimulus type. Resuscitation 97:34–37CrossRefPubMedGoogle Scholar
  49. 49.
    Cruccu G, Aminoff MJ, Curio G, Guerit JM, Kakigi R, Mauguiere F, Rossini PM, Treede RD, Garcia-Larrea L (2008) Recommendations for the clinical use of somatosensory-evoked potentials. Clin Neurophysiol 119:1705–1719CrossRefPubMedGoogle Scholar
  50. 50.
    Bouwes A, Binnekade JM, Kuiper MA, Bosch FH, Zandstra DF, Toornvliet AC, Biemond HS, Kors BM, Koelman JH, Verbeek MM, Weinstein HC, Hijdra A, Horn J (2012) Prognosis of coma after therapeutic hypothermia: a prospective cohort study. Ann Neurol 71:206–212CrossRefPubMedGoogle Scholar
  51. 51.
    Guérit JM, Amantini A, Amodio P, Andersen KV, Butler S, de Weerd A, Facco E, Fischer C, Hantson P, Jäntti V, Lamblin MD, Litscher G, Péréon Y (2009) Consensus on the use of neurophysiological tests in the intensive care unit (ICU): electroencephalogram (EEG), evoked potentials (EP), and electroneuromyography (ENMG). Neurophysiol Clin 39(2):71–83CrossRefPubMedGoogle Scholar
  52. 52.
    Endisch C, Waterstraat G, Storm C, Ploner CJ, Curio G, Leithner C (2016) Cortical somatosensory evoked high-frequency (600 Hz) oscillations predict absence of severe hypoxic encephalopathy after resuscitation. Clin Neurophysiol 127(7):2561–2569CrossRefPubMedGoogle Scholar
  53. 53.
    Zandbergen EG, Hijdra A, de Haan RJ, van Dijk JG, Ongerboer de Visser BW, Spaans F, Tavy DL, Koelman JH (2006) Interobserver variation in the interpretation of SSEPs in anoxic-ischaemic coma. Clin Neurophysiol 117(7):1529–1535CrossRefPubMedGoogle Scholar
  54. 54.
    Torbey MT, Selim M, Knorr J, Bigelow C, Recht L (2000) Quantitative analysis of the loss of distinction between gray and white matter in comatose patients after cardiac arrest. Stroke 31(9):2163–2167CrossRefPubMedGoogle Scholar
  55. 55.
    Choi SP, Park HK, Park KN, Kim YM, Ahn KJ, Choi KH et al (2008) The density ratio of grey to white matter on computed tomography as an early predictor of vegetative state or death after cardiac arrest. Emerg Med J 25(10):666–669CrossRefPubMedGoogle Scholar
  56. 56.
    Metter RB, Rittenberger JC, Guyette FX, Callaway CW (2011) Association between a quantitative CT scan measure of brain edema and outcome after cardiac arrest. Resuscitation 82(9):1180–1185CrossRefPubMedPubMedCentralGoogle Scholar
  57. 57.
    Lee BK, Kim WY, Shin J, Oh JS, Wee JH, Cha KC, Park Y, Choi JH, Jeung KW, Korean Hypothermia Network Investigators (2016) Prognostic value of gray matter to white matter ratio in hypoxic and nonhypoxic cardiac arrest with noncardiac etiology. Am J Emerg Med 34(8):1583–1588CrossRefPubMedGoogle Scholar
  58. 58.
    Scheel M, Storm C, Gentsch A, Nee J, Luckenbach F, Ploner CJ et al (2013) The prognostic value of gray-white-matter ratio in cardiac arrest patients treated with hypothermia. Scand J Trauma Resusc Emerg Med 21:23CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Wu O, Batista LM, Lima FO, Vangel MG, Furie KL, Greer DM (2011) Predicting clinical outcome in comatose cardiac arrest patients using early noncontrast computed tomography. Stroke 42(4):985–992CrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Lee BK, Jeung KW, Lee HY, Jung YH, Lee DH (2013) Combining brain computed tomography and serum neuron specific enolase improves the prognostic performance compared to either alone in comatose cardiac arrest survivors treated with therapeutic hypothermia. Resuscitation 84(10):1387–1392CrossRefPubMedGoogle Scholar
  61. 61.
    Wijdicks EFM, Campeau NG, Miller GM (2001) MR imaging in comatose survivors of cardiac resuscitation. AJNR Am J Neuroradiol 22(8):1561–1565PubMedGoogle Scholar
  62. 62.
    Els T, Kassubek J, Kubalek R, Klisch J (2004) Diffusion-weighted MRI during early global cerebral hypoxia: a predictor for clinical outcome? Acta Neurol Scand 110(6):361–367CrossRefPubMedGoogle Scholar
  63. 63.
    Wu O, Sorensen AG, Benner T, Singhal AB, Furie KL, Greer DM (2009) Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imaging. Radiology 252(1):173–181CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Wijman CAC, Mlynash M, Caulfield AF, Hsia AW, Eyngorn I, Bammer R et al (2009) Prognostic value of brain diffusion weighted imaging after cardiac arrest. Ann Neurol 65(4):394–402CrossRefPubMedPubMedCentralGoogle Scholar
  65. 65.
    Yenari MA, Onley D, Hedehus M, deCrespigny A, Sun GH, Moseley ME et al (2000) Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia. Brain Res 885(2):208–219CrossRefPubMedGoogle Scholar
  66. 66.
    Heradstveit BE, Larsson E-M, Skeidsvoll H, Hammersborg S-M, Wentzel-Larsen T, Guttormsen AB et al (2011) Repeated magnetic resonance imaging and cerebral performance after cardiac arrest—a pilot study. Resuscitation 82(5):549–555CrossRefPubMedGoogle Scholar
  67. 67.
    Luyt CE, Galanaud D, Perlbarg V, Vanhaudenhuyse A, Stevens RD, Gupta R, Besancenot H, Krainik A, Audibert G, Combes A, Chastre J, Benali H, Laureys S, Puybasset L, Neuro Imaging for Coma Emergence and Recovery Consortium (2012) Diffusion tensor imaging to predict long-term outcome after cardiac arrest: a bicentric pilot study. Anesthesiology 117(6):1311–1321CrossRefPubMedGoogle Scholar
  68. 68.
    Norton L, Hutchison RM, Young GB, Lee DH, Sharpe MD, Mirsattari SM (2012) Disruptions of functional connectivity in the default mode network of comatose patients. Neurology 78(3):175–181CrossRefPubMedGoogle Scholar
  69. 69.
    Wijdicks EF, Hijdra A, Young GB, Bassetti CL, Wiebe S (2006) Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 67:203–210CrossRefPubMedGoogle Scholar
  70. 70.
    Fugate JE, Wijdicks EF, Mandrekar J, Claassen DO, Manno EM, White RD, Bell MR, Rabinstein AA (2010) Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann Neurol 68:907–914CrossRefPubMedGoogle Scholar
  71. 71.
    Tiainen M, Roine RO, Pettila V, Takkunen O (2003) Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia. Stroke 34:2881–2886CrossRefPubMedGoogle Scholar
  72. 72.
    Stammet P, Collignon O, Hassager C, Wise MP, Hovdenes J, Åneman A, Horn J, Devaux Y, Erlinge D, Kjaergaard J, Gasche Y, Wanscher M, Cronberg T, Friberg H, Wetterslev J, Pellis T, Kuiper M, Gilson G, Nielsen N, TTM-Trial Investigators (2015) Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33°C and 36°C. J Am Coll Cardiol 65(19):2104–2114CrossRefPubMedGoogle Scholar
  73. 73.
    Rosen H, Rosengren L, Herlitz J, Blomstrand C (1998) Increased serum levels of the S-100 protein are associated with hypoxic brain damage after cardiac arrest. Stroke 29:473–477CrossRefPubMedGoogle Scholar
  74. 74.
    Pfeifer R, Borner A, Krack A, Sigusch HH, Surber R, Figulla HR (2005) Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale. Resuscitation 65:49–55CrossRefPubMedGoogle Scholar
  75. 75.
    Calderon LM, Guyette FX, Doshi AA, Callaway CW, Rittenberger JC, Post Cardiac Arrest Service (2014) Combining NSE and S100B with clinical examination findings to predict survival after resuscitation from cardiac arrest. Resuscitation 85(8):1025–1029CrossRefPubMedPubMedCentralGoogle Scholar
  76. 76.
    Scolletta S, Donadello K, Santonocito C, Franchi F, Taccone FS (2012) Biomarkers as predictors of outcome after cardiac arrest. Expert Rev Clin Pharmacol 5:687–699CrossRefPubMedGoogle Scholar
  77. 77.
    Ames A 3rd, Wright RL, Kowada M, Thurston JM, Majno G (1968) Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol 52(2):437–453PubMedPubMedCentralGoogle Scholar
  78. 78.
    Fischer M, Hossmann KA (1995) No-reflow after cardiac arrest. Intensive Care Med 21(2):132–141CrossRefPubMedGoogle Scholar
  79. 79.
    Lemiale V, Huet O, Vigue B, Mathonnet A, Spaulding C, Mira JP et al (2008) Changes in cerebral blood flow and oxygen extraction during post-resuscitation syndrome. Resuscitation 76(1):17–24CrossRefPubMedGoogle Scholar
  80. 80.
    Buunk G, van der Hoeven JG, Meinders AE (1999) Prognostic significance of the difference between mixed venous and jugular bulb oxygen saturation in comatose patients resuscitated from a cardiac arrest. Resuscitation 41(3):257–262CrossRefPubMedGoogle Scholar
  81. 81.
    Heimburger D, Durand M, Gaide-Chevronnay L, Dessertaine G, Moury PH, Bouzat P, Albaladejo P, Payen JF (2016) Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest. Resuscitation 103:88–93CrossRefPubMedGoogle Scholar
  82. 82.
    Ikeda K, MacLeod DB, Grocott HP, Moretti EW, Ames W, Vacchiano C (2014) The accuracy of a near-infrared spectroscopy cerebral oximetry device and its potential value for estimating jugular venous oxygen saturation. Anesth Analg 119(6):1381–1392CrossRefPubMedPubMedCentralGoogle Scholar
  83. 83.
    Meex I, Dens J, Jans F, Boer W, Vanhengel K, Vundelinckx G et al (2013) Cerebral tissue oxygen saturation during therapeutic hypothermia in post-cardiac arrest patients. Resuscitation 84(6):788–793CrossRefPubMedGoogle Scholar
  84. 84.
    Ahn A, Yang J, Inigo-Santiago L, Parnia S (2014) A feasibility study of cerebral oximetry monitoring during the post-resuscitation period in comatose patients following cardiac arrest. Resuscitation 85(4):522–526CrossRefPubMedGoogle Scholar
  85. 85.
    Storm C, Leithner C, Krannich A, Wutzler A, Ploner CJ, Trenkmann L et al (2014) Regional cerebral oxygen saturation after cardiac arrest in 60 patients–a prospective outcome study. Resuscitation 85(8):1037–1041CrossRefPubMedGoogle Scholar
  86. 86.
    Meynaar IA, Oudemans-van Straaten HM, van der WJ, Verlooy P, Slaats EH, Bosman RJ, van der Spoel JI, Zandstra DF (2003) Serum neuron-specific enolase predicts outcome in post-anoxic coma: a prospective cohort study. Intens Care Med 29:189–195CrossRefGoogle Scholar
  87. 87.
    Torbey MT, Geocadin R, Bhardwaj A (2004) Brain arrest neurological outcome scale (BrANOS): predicting mortality and severe disability following cardiac arrest. Resuscitation 63:55–63CrossRefPubMedGoogle Scholar
  88. 88.
    Oddo M, Rossetti AO (2014) Early multimodal outcome prediction after cardiac arrest in patients treated with hypothermia. Crit Care Med 42(6):1340–1347CrossRefPubMedGoogle Scholar
  89. 89.
    Elmer J, Torres C, Aufderheide TP, Austin MA, Callaway CW, Golan E, Herren H, Jasti J, Kudenchuk PJ, Scales DC, Stub D, Richardson DK, Zive DM, Resuscitation Outcomes Consortium (2016) Association of early withdrawal of life-sustaining therapy for perceived neurological prognosis with mortality after cardiac arrest. Resuscitation 102:127–135CrossRefPubMedGoogle Scholar

Copyright information

© Belgian Neurological Society 2017

Authors and Affiliations

  1. 1.Department of Intensive Care, Hôpital ErasmeUniversité Libre de Bruxelles (ULB)BrusselsBelgium
  2. 2.Department of NeurologyAntwerp University HospitalEdegemBelgium
  3. 3.Department of Anesthesiology, Intensive Care, Emergency Medicine and Pain TherapyZiekenhuis Oost-Limburg ZOLGenkBelgium
  4. 4.Department of Intensive CareGhent University HospitalGhentBelgium
  5. 5.Department of Neurology, Hôpital ErasmeUniversité Libre de Bruxelles (ULB)BrusselsBelgium
  6. 6.Department of Intensive CareUZ LeuvenLeuvenBelgium
  7. 7.Department of Neurology, CHU UCL NamurUniversité Catholique de LouvainYvoirBelgium

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