Acta Neurologica Belgica

, Volume 117, Issue 3, pp 777–778 | Cite as

Could pregabalin cause oculomotor symptoms in lower dose? A case with down beat nystagmus as a side effect

  • Aysen Suzen Ekinci
  • Seyma CiftciEmail author
  • Berfu Cavus
  • Ibrahim Aydogdu
Letter to the Editor

Dear Editor,

Dizziness and ataxia are two known adverse effects of pregabalin use. Oculomotor symptoms may also be seen in pregabalin intoxication although it is reported rarely. Pregabalin can cause these symptoms by reducing excitatory neurotransmitter secretion in the nervous system and by decreasing excitatory inputs in the brainstem. Here, we are reporting a case in which the individual has oculomotor symptoms as a side effect following a low dosage pregabalin treatment.

A 40-year-old female was admitted to our clinic with complaints of diplopia and dizziness. She had experienced complex partial seizures since she was 13 years old and had been taken carbamazepine at 1200 mg/day, lamotrigine 300 mg/day and levetiracetam 2500 mg/day for the last 2 years. Because of her anxiety symptoms, pregabalin 150 mg/day was added on her current anti-epileptic therapy. She stated that diplopia and dizziness were cyclic which lasted for 2–3 h and started after pregabalin treatment. She denied...


Migraine Carbamazepine Lamotrigine Pregabalin Levetiracetam 
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Compliance with ethical standards

This is a case report and there is no foundation.

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from the case included in this article.

Supplementary material

Supplementary material 1 (MP4 1625 kb)


  1. 1.
    Choi JY, Park YM et al (2014) Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication. J Neurol Sci 337(1–2):243–244CrossRefPubMedGoogle Scholar
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    Zaccara G, Gandemi P et al (2011) The adverse event profile of pregabalin: a systematic review and meta-analysis of randomized controlled trials. Epilepsia 52(4):826–836CrossRefPubMedGoogle Scholar
  3. 3.
    Jeong SH, Kim YS et al (2015) Transient positive horizontal head impulse test in pregabalin intoxication. Journal of Epilepsy Research 5(2):101–103CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Belgian Neurological Society 2016

Authors and Affiliations

  • Aysen Suzen Ekinci
    • 1
  • Seyma Ciftci
    • 1
    Email author
  • Berfu Cavus
    • 2
  • Ibrahim Aydogdu
    • 1
  1. 1.Department of Neurology, Faculty of MedicineEge UniversityIzmirTurkey
  2. 2.Department of NeurologyTurgutlu State HospitalManisaTurkey

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