Chronic negative myoclonus with hypercapnic encephalopathy
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“Hypercapnic encephalopathy syndrome” is a respiratory encephalopathy that is a potentially reversible condition associated with acute respiratory failure and severely decompensated respiratory hypercapnic acidosis . There have been few reports of asterixis caused by acute respiratory failure and the presence of asterixis is one of the prognostic markers of acute exacerbations of chronic obstructive pulmonary disease (COPD) .
Here we report on a 66-year-old man with COPD accompanied by chronic negative myoclonus. The patient had been healthy prior to the sudden development of myoclonus in the forearm and trunk 4 months earlier. This symptom was evident at rest and pronounced with an out-stretched hand posture. The patient denied any significant medical history including pulmonary diseases or drug exposure.
The physical examination was normal and neurological examination revealed jerky and brisk myoclonic movements of the arms and trunk, and a negative myoclonus that...
KeywordsChronic Obstructive Pulmonary Disease Acute Respiratory Failure Video Segment Focal Seizure Hypercapnic Acidosis
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Conflict of interest
The authors have no conflicts of interest or financial support to report.
The institutional review board at St. Mary’s Hospital approved this case report.
The patients have consented to the submission of the case report to the journal.
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