Acta Neurologica Belgica

, Volume 116, Issue 1, pp 57–63 | Cite as

Low vitamin D levels in healthy controls and patients with autoimmune neuromuscular disorders in Greece

  • Elisabeth Chroni
  • Nikolaos Dimisianos
  • Anna Rostedt Punga
Original Article


Normal autoimmune function is dependent on adequate levels of activated vitamin D, 25 hydroxy vitamin D [25(OH)D]. A recent study presented deficiency of 25(OH)D levels in Swedish MG patients. We aimed to study 25(OH)D levels in patients with MG and autoimmune polyneuropathies (PNP) at a southern latitude in Greece. Plasma levels of 25(OH)D were analyzed in Greek patients with MG (n = 19), immune-mediated PNP (N = 11) and in 30 Greek healthy age- and sex-matched controls. Ten MG patients received supplementation with vitamin D3. The MG Composite Score (MGC) and MG quality of life assessed disease severity in MG patients, whereas the INCAT Disability Scale assessed clinical features in the PNP patients. MG patients with and without vitamin D3 supplementation had higher 25(OH)D levels (mean 58.8 ± 16.3 and 62.0 ± 22.4 nmol/L, respectively) than PNP patients (mean 42.1 ± 11.5 nmol/L, p = 0.01) and healthy controls (mean 45.7 ± 13.8 nmol/L, p = 0.01). Plasma 25(OH)D levels was lower with age in all groups. There were no correlations between 25(OH)D and disease duration, MGC score, or INCAT score. Vitamin D deficiency was found in all Greek patient groups and healthy controls. Levels of 25(OH)D were higher in MG patients with as well as without vitamin D supplementation compared to healthy controls, whereas CIDP/GBS patients had levels similar to controls.


Myasthenia gravis Guillain–Barré syndrome Vitamin D Autoimmune polyneuropathy 



This work was supported by Lars Hiertas memorial foundation and Selanders foundation (ARP).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical and informed consent

All subjects signed written informed consent prior to inclusion into the study. The study protocol was approved by the Ethics Committee of PUH (No of approval: 37 /25-1-2012).


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Copyright information

© Belgian Neurological Society 2015

Authors and Affiliations

  • Elisabeth Chroni
    • 1
  • Nikolaos Dimisianos
    • 1
  • Anna Rostedt Punga
    • 2
  1. 1.Department of Neurology, School of MedicineUniversity of PatrasPatrasGreece
  2. 2.Department of Clinical Neurophysiology, Institute of Neuroscience, Uppsala University HospitalUppsala UniversityUppsalaSweden

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