Acta Neurologica Belgica

, Volume 113, Issue 4, pp 411–414 | Cite as

Fatigue in multiple sclerosis: relationship with disease duration, physical disability, disease pattern, age and sex

  • Mahsa GhajarzadehEmail author
  • Rozita Jalilian
  • Ghazaleh Eskandari
  • Mohammad Ali Sahraian
  • Amirreza Azimi
  • Mehdi Mohammadifar
Original Article


To evaluate the relationship between disease duration, disability, disease pattern, age and sex with fatigue in MS patients. One hundred and seventy-three clinically definite MS patients and 87 age-matched healthy controls enrolled in this cross sectional study. Demographic data (sex, age), duration of the disease and disease pattern extracted from patient’s files and Kurtzke Expanded Disability Status Scale (EDSS) were recorded for each patient by an expert neurologist. Participants were asked to answer the validated and reliable Persian version of beck depression inventory (BDI) and FSS (fatigue severity score) questionnaires. Mean FSS and BDI scores were significantly different between patients and controls (p < 0.001). Patients with longer disease duration, higher EDSS and progressive type of disease had significantly higher FSS and BDI scores. Although men had higher EDSS, FSS and BDI scores were similar in both sex groups. FSS was significantly correlated with age, disease duration, BDI and EDSS. The analysis of covariance revealed that there is no difference in the covariance-adjusted means for fatigue among two disease groups (relapsing remitting and secondary progressive) except for EDSS. MS patients with longer disease duration, higher EDSS and progressive type of disease suffer from fatigue more than cases with lower EDSS, duration of disease and relapsing type of the disease.


Fatigue Multiple sclerosis Depression Disability Disease pattern 


Conflict of interest



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Copyright information

© Belgian Neurological Society 2013

Authors and Affiliations

  • Mahsa Ghajarzadeh
    • 1
    Email author
  • Rozita Jalilian
    • 2
  • Ghazaleh Eskandari
    • 1
  • Mohammad Ali Sahraian
    • 3
  • Amirreza Azimi
    • 4
  • Mehdi Mohammadifar
    • 5
  1. 1.Brain and Spinal Injury Research Center (BASIR)Tehran University of Medical SciencesTehranIran
  2. 2.Tehran University of Medical Sciences, Imam HospitalTehranIran
  3. 3.Department of Neurology, Sina Hospital, MS Research CenterTehran University of Medical SciencesTehranIran
  4. 4.Department of Neurology, Sina Hospital, MS Research Center, Brain and Spinal Injury Research Center (BASIR)Tehran University of Medical SciencesTehranIran
  5. 5.Department of RadiologyZanjan University of Medical SciencesZanjanIran

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